Drug Information
Drug General Information | Top | |||
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Drug ID |
D02SQF
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Former ID |
DIB018623
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Drug Name |
4-methylhistamine
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Synonyms |
4-Methylhistamine; 5-Methylhistamine; 36507-31-0; 5(4)-Methylhistamine; 1H-Imidazole-4-ethanamine, 5-methyl-; 2-(5-methyl-1H-imidazol-4-yl)ethanamine; UNII-54ST71P9EE; 1H-Imidazo-4-ethanamine, 5-methyl-; 54ST71P9EE; CHEBI:74760; IMIDAZOLE, 4-(2-AMINOETHYL)-5-METHYL-; 2-(5-Methyl-4-imidazolyl)ethylamine; 2-(4-METHYL-1H-IMIDAZOL-5-YL)ETHANAMINE; p-methylhistamine; Methylhistamine-4; 5-(2-Aminoethyl)-4-methylimidazole; AC1L1XS2; SCHEMBL606803; CHEMBL275443; GTPL1269; SCHEMBL11452941; BDBM22880; UGYXPZQILZRKJJ-UHFFFAOYSA-N
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C6H11N3
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Canonical SMILES |
CC1=C(N=CN1)CCN
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InChI |
1S/C6H11N3/c1-5-6(2-3-7)9-4-8-5/h4H,2-3,7H2,1H3,(H,8,9)
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InChIKey |
UGYXPZQILZRKJJ-UHFFFAOYSA-N
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CAS Number |
CAS 36507-31-0
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PubChem Compound ID | ||||
PubChem Substance ID |
8175026, 15218924, 34678762, 47285816, 48029603, 49846694, 49979068, 57312047, 78084230, 84974637, 85083159, 85208920, 96024150, 103173326, 104326639, 126663318, 129366978, 134999313, 135649802, 137005456, 141766906, 142022261, 148176123, 162219797, 164174740, 170521455, 177748554, 179294129, 198955968, 216076725, 223668744, 224932212, 226909039, 236636659, 241065799, 249539400, 249769736, 249963149, 251874886
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ChEBI ID |
CHEBI:74760
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Target and Pathway | Top | |||
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Target(s) | Histamine H4 receptor (H4R) | Target Info | Agonist | [2] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Reactome | Histamine receptors | |||
G alpha (i) signalling events | ||||
WikiPathways | GPCR ligand binding | |||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1269). | |||
REF 2 | Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives. Br J Pharmacol. 2006 Apr;147(7):744-54. |
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