Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02SBQ
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| Former ID |
DAP001029
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| Drug Name |
Urofollitropin
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| Synonyms |
Bravelle; Fertinex; Metrodin; Urofollitrophin; Fertinorm HP; Bravelle (TN); Fertinex (TN); Follistim (TN); Gonal-F(TN); (4-Threonine)oxytocin; 1,2-Dithia-5,8,11,14,17-penaazacycloeicosane, cyclic peptide deriv.; 4-(L-Threonine)oxytocin
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| Drug Type |
Small molecular drug
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| Indication | Female infertility [ICD-11: GA31.Z; ICD-9: 628] | Approved | [1] | |
| Therapeutic Class |
Fertility Agents
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| Structure |
 |
Download2D MOL |
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| Formula |
C42H65N11O12S2
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| Canonical SMILES |
CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)C(C)O
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| InChI |
1S/C42H65N11O12S2/c1-6-21(4)33-40(63)52-34(22(5)54)41(64)49-28(16-31(44)56)37(60)50-29(19-67-66-18-25(43)35(58)47-27(38(61)51-33)15-23-9-11-24(55)12-10-23)42(65)53-13-7-8-30(53)39(62)48-26(14-20(2)3)36(59)46-17-32(45)57/h9-12,20-22,25-30,33-34,54-55H,6-8,13-19,43H2,1-5H3,(H2,44,56)(H2,45,57)(H,46,59)(H,47,58)(H,48,62)(H,49,64)(H,50,60)(H,51,61)(H,52,63)
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| InChIKey |
ZDRRIRUAESZNIH-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ADReCS Drug ID | BADD_D02319 | |||
| SuperDrug ATC ID |
G03GA04
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Follicle-stimulating hormone receptor (FSHR) | Target Info | Binder | [2] |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Ovarian steroidogenesis | ||||
| Pathwhiz Pathway | Vasopressin Regulation of Water Homeostasis | |||
| Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone | ||||
| Reactome | Hormone ligand-binding receptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Ovarian Infertility Genes | ||||
| Peptide GPCRs | ||||
| FSH signaling pathway | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 2 | Follicle-stimulating hormone in clinical practice: an update. Treat Endocrinol. 2004;3(3):161-71. | |||
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