Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02QWJ
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| Former ID |
DIB003995
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| Drug Name |
EREMOMYCIN
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| Synonyms |
Hexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid; (4"R)-22-O-(3-Amino-2,3,6-trideoxy-3-C-methyl-alpha-L-arabino-hexopyranosyl)-19-dechlorovancomycin; Etrahydroxy-6-(N2-methylleucylamido)-2,5,24,38,39-pentaoxo-2,3,4,5,6,7,23,24,25,26,36,37,38,38a-tetradecahydro-1H,22H-8,11:18,21-dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno[1,6,9]oxadiazacyclo; 22-(3-Amino-2,3,6-trideoxy-3-C-methyl-L-arabinohexopyranosyloxy)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-L-arabinohexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10-chloro-7,28,30,32-t; 3-(Carbamoylmethyl)-10-chloro-7,28,30,32-tetrahydroxy-6-(N2-methylleucylamido)-2,5,24,38,39-pentaoxo-22-(4-epi-vancosaminyloxy)-44-[2-O-(4-epi-vancosaminyl)-beta-D-glucopyranosyloxy]-2,3,4,5,6,7,23,24; 35-dimetheno[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid
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| Indication | Bacterial infection [ICD-11: 1A00-1C4Z; ICD-10: A00-B99] | Discontinued in Phase 2 | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C73H89ClN10O26
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| Canonical SMILES |
CC1C(C(CC(O1)OC2C(C(C(OC2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)C(C(C(=O)NC(C(=O)NC5C(=O)NC7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)C(NC(=O)C(C(C1=CC=C(O4)C=C1)OC1CC(C(C(O1)C)O)(C)N)NC7=O)C(=O)O)CC(=O)N)NC(=O)C(CC(C)C)NC)O)Cl)CO)O)O)(C)N)O
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| InChI |
1S/C73H89ClN10O26/c1-27(2)16-39(78-7)64(95)83-54-56(90)32-11-15-43(38(74)18-32)106-45-20-33-19-44(60(45)110-71-61(58(92)57(91)46(26-85)107-71)109-49-25-73(6,77)63(94)29(4)104-49)105-35-12-8-30(9-13-35)59(108-48-24-72(5,76)62(93)28(3)103-48)55-69(100)82-53(70(101)102)37-21-34(86)22-42(88)50(37)36-17-31(10-14-41(36)87)51(66(97)84-55)81-67(98)52(33)80-65(96)40(23-47(75)89)79-68(54)99/h8-15,17-22,27-29,39-40,46,48-49,51-59,61-63,71,78,85-88,90-94H,16,23-26,76-77H2,1-7H3,(H2,75,89)(H,79,99)(H,80,96)(H,81,98)(H,82,100)(H,83,95)(H,84,97)(H,101,102)/t28-,29-,39+,40-,46+,48-,49-,51+,52+,53-,54+,55-,56+,57+,58-,59+,61+,62-,63-,71-,72-,73-/m0/s1
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| InChIKey |
UECIPBUIMXSXEI-BNSVOVDNSA-N
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| CAS Number |
CAS 110865-90-2
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bacterial Cell membrane (Bact CM) | Target Info | Modulator | [2] |
| References | Top | |||
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| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002322) | |||
| REF 2 | Role of the glycopeptide framework in the antibacterial activity of hydrophobic derivatives of glycopeptide antibiotics. J Med Chem. 2003 Mar 27;46(7):1204-9. | |||
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