Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02MVG
|
|||
| Former ID |
DIB010154
|
|||
| Drug Name |
AMG-548
|
|||
| Synonyms |
P38 MAP kinase inhibitor, Amgen
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Inflammation [ICD-11: 1A00-CA43.1] | Terminated | [1] | |
| Company |
Amgen Inc
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C29H27N5O
|
|||
| Canonical SMILES |
CN1C(=O)C(=C(N=C1NCC(CC2=CC=CC=C2)N)C3=CC=NC=C3)C4=CC5=CC=CC=C5C=C4
|
|||
| InChI |
1S/C29H27N5O/c1-34-28(35)26(24-12-11-21-9-5-6-10-23(21)18-24)27(22-13-15-31-16-14-22)33-29(34)32-19-25(30)17-20-7-3-2-4-8-20/h2-16,18,25H,17,19,30H2,1H3,(H,32,33)/t25-/m0/s1
|
|||
| InChIKey |
RQVKVJIRFKVPBF-VWLOTQADSA-N
|
|||
| CAS Number |
CAS 864249-60-5
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Stress-activated protein kinase (p38) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019881) | |||
| REF 2 | p38 MAP kinase inhibitors: many are made, but few are chosen. Curr Opin Drug Discov Devel. 2005 Jul;8(4):421-30. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.