Drug Information
Drug General Information | Top | |||
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Drug ID |
D02KUO
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Drug Name |
Cenegermin
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Synonyms |
cenegermin; Cenegermin [INN]; UNII-B6E7K36KT8; B6E7K36KT8; Human beta-nerve growth factor (beta-ngf)-(1-118)- peptide (non-covalent dimer) produced in escherichia coli nerve growth factor
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Drug Type |
Antibody
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Indication | Neurotrophic keratitis [ICD-11: 9A74; ICD-10: H16.2] | Approved | [1] | |
Company |
Domp
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PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Low-affinity nerve growth factor receptor (NGFR) | Target Info | Agonist | [1] |
KEGG Pathway | Ras signaling pathway | |||
Rap1 signaling pathway | ||||
Cytokine-cytokine receptor interaction | ||||
PI3K-Akt signaling pathway | ||||
Neurotrophin signaling pathway | ||||
Transcriptional misregulation in cancer | ||||
Pathway Interaction Database | p75(NTR)-mediated signaling | |||
Neurotrophic factor-mediated Trk receptor signaling | ||||
Reactome | Axonal growth inhibition (RHOA activation) | |||
NRAGE signals death through JNK | ||||
p75NTR negatively regulates cell cycle via SC1 | ||||
Regulated proteolysis of p75NTR | ||||
NADE modulates death signalling | ||||
NRIF signals cell death from the nucleus | ||||
p75NTR recruits signalling complexes | ||||
NF-kB is activated and signals survival | ||||
Axonal growth stimulation | ||||
WikiPathways | Spinal Cord Injury | |||
BDNF signaling pathway | ||||
Signalling by NGF |
References | Top | |||
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REF 1 | 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. |
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