Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02JKY
|
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| Former ID |
DNCL003080
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| Drug Name |
TD-9855
|
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| Indication | Pain [ICD-11: MG30-MG3Z] | Phase 2 | [1] | |
| Orthostatic hypotension [ICD-11: BA21; ICD-10: I95.1; ICD-9: 458] | Phase 1 | [2] | ||
| Structure |
 |
Download2D MOL |
||
| Formula |
C18H18F3NO
|
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| Canonical SMILES |
C1CNCCC1C2=CC=CC=C2COC3=C(C=C(C=C3F)F)F
|
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| InChI |
1S/C18H18F3NO/c19-14-9-16(20)18(17(21)10-14)23-11-13-3-1-2-4-15(13)12-5-7-22-8-6-12/h1-4,9-10,12,22H,5-8,11H2
|
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| InChIKey |
TZIALEBTHQWNAO-UHFFFAOYSA-N
|
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| CAS Number |
CAS 1227056-84-9
|
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Norepinephrine transporter (NET) | Target Info | Modulator | [1] |
| Serotonin transporter (SERT) | Target Info | Modulator | [1] | |
| KEGG Pathway | Serotonergic synapse | |||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | Adrenaline and noradrenaline biosynthesis | |||
| 5HT1 type receptor mediated signaling pathway | ||||
| 5HT2 type receptor mediated signaling pathway | ||||
| 5HT3 type receptor mediated signaling pathway | ||||
| 5HT4 type receptor mediated signaling pathway | ||||
| Reactome | Na+/Cl- dependent neurotransmitter transporters | |||
| WikiPathways | Monoamine Transport | |||
| NRF2 pathway | ||||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||||
| SIDS Susceptibility Pathways | ||||
| Synaptic Vesicle Pathway | ||||
| Serotonin Transporter Activity | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Preclinical to clinical translation of CNS transporter occupancy of TD-9855, a novel norepinephrine and serotonin reuptake inhibitor. Int J Neuropsychopharmacol. 2014 Dec 13;18(2). pii: pyu027. | |||
| REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
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