Drug Information
Drug General Information | Top | |||
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Drug ID |
D02JIN
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Former ID |
DIB005192
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Drug Name |
264W94
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Synonyms |
GW-264
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Drug Type |
Small molecular drug
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Indication | Hyperlipidaemia [ICD-11: 5C80; ICD-10: E78.5] | Phase 2 | [1], [2] | |
Company |
Glaxo Wellcome plc
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Structure |
Download2D MOL |
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Formula |
C23H31NO4S
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Canonical SMILES |
CCCCC1(CS(=O)(=O)C2=CC(=C(C=C2C(N1)C3=CC=CC=C3)OC)OC)CC
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InChI |
1S/C23H31NO4S/c1-5-7-13-23(6-2)16-29(25,26)21-15-20(28-4)19(27-3)14-18(21)22(24-23)17-11-9-8-10-12-17/h8-12,14-15,22,24H,5-7,13,16H2,1-4H3/t22-,23-/m1/s1
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InChIKey |
CKFWDLFFXXVSBJ-DHIUTWEWSA-N
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CAS Number |
CAS 178259-25-1
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Ileal sodium/bile acid cotransporter (SLC10A2) | Target Info | Modulator | [2] |
KEGG Pathway | Bile secretion | |||
Reactome | Recycling of bile acids and salts | |||
WikiPathways | Bile acid and bile salt metabolism |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6529). | |||
REF 2 | Inhibition of apical sodium-dependent bile acid transporter as a novel treatment for diabetes. Am J Physiol Endocrinol Metab. 2012 Jan 1;302(1):E68-76. |
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