Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02HSB
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| Former ID |
DCL000502
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| Drug Name |
Cabazitaxel
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| Synonyms |
Jevtana; Taxoid XRP6258; Jevtana (TN)
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| Drug Type |
Small molecular drug
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| Indication | Breast cancer [ICD-11: 2C60-2C65] | Approved | [1], [2] | |
| Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 2 | [1], [2] | ||
| Company |
Sanofi-Aventis
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| Structure |
 |
Download2D MOL |
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| Formula |
C45H57NO14
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| Canonical SMILES |
CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)OC)C)OC
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| InChI |
1S/C45H57NO14/c1-24-28(57-39(51)33(48)32(26-17-13-11-14-18-26)46-40(52)60-41(3,4)5)22-45(53)37(58-38(50)27-19-15-12-16-20-27)35-43(8,36(49)34(55-10)31(24)42(45,6)7)29(54-9)21-30-44(35,23-56-30)59-25(2)47/h11-20,28-30,32-35,37,48,53H,21-23H2,1-10H3,(H,46,52)/t28-,29-,30+,32-,33+,34+,35-,37-,43+,44-,45+/m0/s1
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| InChIKey |
BMQGVNUXMIRLCK-OAGWZNDDSA-N
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| CAS Number |
CAS 183133-96-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
14816121, 16397389, 24148765, 45276379, 74383470, 99443289, 103771484, 124490495, 126731257, 131408692, 135263012, 135611139, 142086497, 152159611, 160967906, 162202442, 162224746, 163620896, 163686217, 164834203, 174007406, 175267969, 176484653, 178103404, 184812013, 189628693, 198992513, 210024082, 221678515, 223662379, 224518787, 226540589, 243273959, 249582877, 251916124, 251917472, 251971415, 252110248, 252215082
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| ChEBI ID |
CHEBI:63584
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| ADReCS Drug ID | BADD_D00328 | |||
| SuperDrug ATC ID |
L01CD04
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tubulin (TUB) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6798). | |||
| REF 2 | Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. | |||
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