Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D02HNM
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| Former ID |
DNC001116
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| Drug Name |
Phaclofen
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| Synonyms |
Phaclofen; 114012-12-3; [3-amino-2-(4-chlorophenyl)propyl]phosphonic acid; (3-Amino-2-(4-chlorophenyl)propyl)phosphonic acid; Phosphonic acid, (3-amino-2-(4-chlorophenyl)propyl)-; 3-Amino-2-(4-chlorophenyl)propylphosphonic acid; 3-Amino-2-(4-chlorophenyl) propylphosphonic acid; Phosphonic acid,P-[3-amino-2-(4-chlorophenyl)propyl]-; SR-01000075640; Phaclofen, solid; beta-(4-Chlorophenyl)-3-aminopropylphosphonic acid; ACMC-20djlx; 108351-35-5; AC1Q3NDJ; AC1L1BWO; Biomol-NT_000256; Lopac0_000967; SCHEMBL339995; GTPL1091
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C9H13ClNO3P
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| Canonical SMILES |
C1=CC(=CC=C1C(CN)CP(=O)(O)O)Cl
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| InChI |
1S/C9H13ClNO3P/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H2,12,13,14)
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| InChIKey |
VSGNGLJPOGUDON-UHFFFAOYSA-N
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| CAS Number |
CAS 114012-12-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5671788, 7978529, 8151214, 14823423, 17405525, 24278189, 26751635, 29220846, 47440471, 48035342, 48259452, 50067803, 50104322, 50104323, 52247142, 53778073, 57320962, 85088543, 85209238, 85231172, 90340885, 91721931, 92303274, 103064787, 103085802, 104298293, 117462745, 121361779, 123101031, 124750132, 124881011, 124881012, 126407148, 129519702, 134222867, 134340355, 135066309, 135090812, 135650815, 137009766, 162091866, 162311569, 162776879, 163564921, 164814867, 184548044, 204362019, 226675390, 241181562, 241337627
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Gamma-aminobutyric acid B receptor (GABBR) | Target Info | Antagonist | [2], [3] |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| GABAergic synapse | ||||
| Estrogen signaling pathway | ||||
| Morphine addiction | ||||
| Reactome | Activation of G protein gated Potassium channels | |||
| G alpha (i) signalling events | ||||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | ||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Potassium Channels | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1091). | |||
| REF 2 | Astrocytes and interneurons in memory processing in the chick hippocampus: roles for G-coupled protein receptors, GABA(B) and mGluR1. Neurochem Res. 2009 Oct;34(10):1712-20. | |||
| REF 3 | The role of group II and III metabotropic glutamate receptors in modulation of miniature synaptic activity in frog spinal cord motoneurons. Tsitologiia. 2008;50(9):747-56. | |||
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