Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D02HNG
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| Former ID |
DCL000567
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| Drug Name |
MK-0752
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| Synonyms |
MK-0752; 471905-41-6; MK0752; UNII-9JD9B4S53T; MK 0752; cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid; 9JD9B4S53T; 3-((1r,4s)-4-((4-chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid; 3-(cis-4-((4-Chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid; 3-((1r,4s)-4-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid; 952578-68-6; cc-14; C21H21ClF2O4S; MLS006011072; SCHEMBL756249; SCHEMBL756248; SCHEMBL756247; CHEMBL3392635
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| Drug Type |
Small molecular drug
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| Indication | Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9; ICD-9: 331] | Phase 2 | [1] | |
| Company |
Merck
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| Structure |
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Download2D MOL |
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| Formula |
C21H21ClF2O4S
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| Canonical SMILES |
C1CC(CCC1CCC(=O)O)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl
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| InChI |
1S/C21H21ClF2O4S/c22-15-2-5-17(6-3-15)29(27,28)21(18-13-16(23)4-7-19(18)24)11-9-14(10-12-21)1-8-20(25)26/h2-7,13-14H,1,8-12H2,(H,25,26)
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| InChIKey |
XCGJIFAKUZNNOR-UHFFFAOYSA-N
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| CAS Number |
CAS 471905-41-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
14759485, 26656969, 44839430, 76228635, 135293803, 136340317, 136349535, 136350005, 136367666, 137276028, 138981598, 144116224, 144116225, 152258282, 160647121, 162011365, 162038054, 162202770, 164033271, 164042765, 164193934, 174529467, 186022490, 223397844, 223701381, 223705128, 227040993, 227040994, 227040995, 241381736, 242559493, 242671661, 244152522, 245650540, 249492837, 249820123, 249860971, 250224828, 251963155, 252073854, 252109926, 252215813, 252437558, 252451651
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | Determination of the gamma-secretase inhibitor MK-0752 in human plasma by online extraction and electrospray tandem mass spectrometry (HTLC-ESI-MS/MS). J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Sep 1;878(25):2348-52. | |||
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