Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D02GIU
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| Former ID |
DAP000632
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| Drug Name |
Cilastatin
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| Synonyms |
Cilastatina; Cilastatine; Cilastatinum; Cilastatin Monosodium Salt; Cilastatin acid; Cilastatina [Spanish]; Cilastatine [French]; Cilastatinum [Latin]; MK0791; Cilastatin (INN); Cilastatin [INN:BAN]; MK-791; (2Z)-7-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}-2-({[(1S)-2,2-dimethylcyclopropyl]carbonyl}amino)hept-2-enoic acid; (Z)-(S)-6-carboxy-6-[(S)-2,2-dimethylcyclopropanecarboxamido]hex-5-enyl-L-cysteine; (Z)-7-[(2R)-2-amino-3-hydroxy-3-oxopropyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoic acid
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| Drug Type |
Small molecular drug
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| Indication | Bacterial infection [ICD-11: 1A00-1C4Z; ICD-10: A00-B99] | Approved | [1], [2] | |
| Therapeutic Class |
Antibiotics
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| Company |
Merck
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| Structure |
 |
Download2D MOL |
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| Formula |
C16H26N2O5S
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| Canonical SMILES |
CC1(CC1C(=O)NC(=CCCCCSCC(C(=O)O)N)C(=O)O)C
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| InChI |
1S/C16H26N2O5S/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23)/b12-6-/t10-,11+/m1/s1
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| InChIKey |
DHSUYTOATWAVLW-WFVMDLQDSA-N
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| CAS Number |
CAS 82009-34-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
4819, 11621425, 14803328, 15447933, 43028732, 46505611, 49835265, 49975600, 50125939, 50707339, 51091997, 57367468, 92719468, 93166940, 93578311, 103203584, 104133316, 114548412, 126628216, 126655280, 126671064, 131327190, 134222536, 134337922, 135014438, 137129408, 137256909, 142803744, 152101563, 160846604, 160964834, 175267016, 178101856, 179680678, 196105993, 223682361, 226422952, 250133500
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| ChEBI ID |
CHEBI:3697
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dehydropeptidase I (DPEP1) | Target Info | Inhibitor | [3] |
| BioCyc | Leukotriene biosynthesis | |||
| Reactome | Aflatoxin activation and detoxification | |||
| WikiPathways | Eicosanoid Synthesis | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5166). | |||
| REF 2 | Formulary review of the carbapenems: comparison of imipenem/cilastatin and meropenem. Conn Med. 1998 Mar;62(3):165-9. | |||
| REF 3 | Pharmacokinetic study of pleural fluid penetration of carbapenem antibiotic agents in chemical pleurisy. Respir Med. 2006 Feb;100(2):324-31. | |||
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