Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02EMR
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| Former ID |
DCL000752
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| Drug Name |
Cilomilast
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| Synonyms |
Ariflo; CIO; SB 207499; SB207499; Ariflo (TN); Cilomilast [USAN:INN]; SB-207499; Ariflo, SB-207499,Cilomilast; Cilomilast (JAN/USAN/INN); CIS-4-CYANO-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]CYCLOHEXANECARBOXYLIC ACID; Cis-4-Cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexanecarboxylic acid; Cis-4-Cyano-4-(3-(cyclopentyloxy)-4-methoxyphenyl)cyclohexanecarboxylic acid; Cis-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)-4-cyanocyclohexane-1-carboxylic acid; 4-cyano-4-(3-cyclopentoxy-4-methoxy-phenyl)-cyclohexane-1-carboxylic acid; 4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexane-1-carboxylic acid
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| Drug Type |
Small molecular drug
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| Indication | Bronchitis [ICD-11: CA20; ICD-10: J40] | Discontinued in Phase 3 | [1], [2] | |
| Chronic obstructive pulmonary disease [ICD-11: CA22; ICD-10: J44, J44.9] | Discontinued in Phase 3 | [1], [2] | ||
| Emphysema [ICD-11: CA21] | Discontinued in Phase 3 | [1], [2] | ||
| Company |
GlaxoSmithKline
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| Structure |
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Download2D MOL |
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| Formula |
C20H25NO4
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| Canonical SMILES |
COC1=C(C=C(C=C1)C2(CCC(CC2)C(=O)O)C#N)OC3CCCC3
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| InChI |
1S/C20H25NO4/c1-24-17-7-6-15(12-18(17)25-16-4-2-3-5-16)20(13-21)10-8-14(9-11-20)19(22)23/h6-7,12,14,16H,2-5,8-11H2,1H3,(H,22,23)
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| InChIKey |
CFBUZOUXXHZCFB-UHFFFAOYSA-N
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| CAS Number |
CAS 153259-65-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7848767, 7886612, 10251041, 12014847, 14827338, 14900458, 15722497, 40967267, 40967286, 46227735, 46393565, 46393575, 46505062, 46515098, 47657134, 48105226, 49957697, 50112773, 53790097, 57347308, 80059282, 93308090, 93310591, 99437274, 103587454, 103994769, 104430347, 124757262, 125164066, 125536625, 127615918, 127615919, 127615920, 131300126, 131349019, 131480881, 134339242, 135106954, 136367428, 136367988, 137102438, 137246277, 140119543, 141754319, 141948760, 144115831, 144206070, 152106616, 152258266, 152344295
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| ChEBI ID |
CHEBI:94683
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Phosphodiesterase 4 (PDE4) | Target Info | Inhibitor | [3] |
| Phosphodiesterase 4A (PDE4A) | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Purine metabolism | |||
| cAMP signaling pathway | ||||
| Morphine addiction | ||||
| Reactome | DARPP-32 events | |||
| G alpha (s) signalling events | ||||
| WikiPathways | G Protein Signaling Pathways | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7407). | |||
| REF 2 | Emerging drugs for asthma. Expert Opin Emerg Drugs. 2008 Dec;13(4):643-53. | |||
| REF 3 | Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. | |||
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