Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02DES
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| Former ID |
DAP000095
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| Drug Name |
Anakinra
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| Synonyms |
Kineret; Kineret (TN); Anakinra (USAN/INN)
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| Indication | Rheumatoid arthritis [ICD-11: FA20] | Approved | [1], [2] | |
| Therapeutic Class |
Antiinflammatory Agents
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| Company |
Amgen Inc
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| PubChem Substance ID | ||||
| ADReCS Drug ID | BADD_D00141 | |||
| SuperDrug ATC ID |
L04AC03
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Interleukin 1 receptor type 1 (IL1R1) | Target Info | Antagonist | [3], [4] |
| KEGG Pathway | MAPK signaling pathway | |||
| Cytokine-cytokine receptor interaction | ||||
| NF-kappa B signaling pathway | ||||
| Apoptosis | ||||
| Osteoclast differentiation | ||||
| Hematopoietic cell lineage | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Amoebiasis | ||||
| HTLV-I infection | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| IL2 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | ||||
| Panther Pathway | p38 MAPK pathway | |||
| Pathway Interaction Database | IL12-mediated signaling events | |||
| IL1-mediated signaling events | ||||
| Reactome | Interleukin-1 signaling | |||
| WikiPathways | Monoamine Transport | |||
| Hypertrophy Model | ||||
| MAPK Signaling Pathway | ||||
| IL1 and megakaryotyces in obesity | ||||
| Structural Pathway of Interleukin 1 (IL-1) | ||||
| Spinal Cord Injury | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| IL-1 signaling pathway | ||||
| Interleukin-1 signaling | ||||
| Apoptosis Modulation and Signaling | ||||
| Serotonin Transporter Activity | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6972). | |||
| REF 2 | Molecular targets of rheumatoid arthritis. Inflamm Allergy Drug Targets. 2008 Mar;7(1):53-66. | |||
| REF 3 | IL-1 receptor antagonism and muscle gene expression in patients with type 2 diabetes. Eur Cytokine Netw. 2009 Jun 1;20(2):81-87. | |||
| REF 4 | Complications and adverse reactions in the use of newer biologic agents. Semin Cutan Med Surg. 2007 Mar;26(1):6-14. | |||
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