Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02DDM
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| Former ID |
DNC007232
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| Drug Name |
2-(2-methoxyphenyl)-6-morpholino-4H-pyran-4-one
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| Synonyms |
CHEMBL105256; 2-(2-methoxyphenyl)-6-morpholino-4H-pyran-4-one; SCHEMBL3538816; BDBM50132363; 2-Morpholino-6-(2-methoxyphenyl)-4H-pyran-4-one
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C16H17NO4
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| Canonical SMILES |
COC1=CC=CC=C1C2=CC(=O)C=C(O2)N3CCOCC3
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| InChI |
1S/C16H17NO4/c1-19-14-5-3-2-4-13(14)15-10-12(18)11-16(21-15)17-6-8-20-9-7-17/h2-5,10-11H,6-9H2,1H3
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| InChIKey |
ZDNMYLJFYAXNHH-UHFFFAOYSA-N
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| CAS Number |
CAS 155906-26-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA-dependent protein kinase catalytic (PRKDC) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Non-homologous end-joining | |||
| Cell cycle | ||||
| NetPath Pathway | IL1 Signaling Pathway | |||
| Pathway Interaction Database | DNA-PK pathway in nonhomologous end joining | |||
| Coregulation of Androgen receptor activity | ||||
| Class I PI3K signaling events mediated by Akt | ||||
| BARD1 signaling events | ||||
| Reactome | Nonhomologous End-Joining (NHEJ) | |||
| WikiPathways | DNA Damage Response | |||
| Non-homologous end joining | ||||
| FAS pathway and Stress induction of HSP regulation | ||||
| Cytosolic sensors of pathogen-associated DNA | ||||
| Retinoblastoma (RB) in Cancer | ||||
| Prostate Cancer | ||||
| Double-Strand Break Repair | ||||
| Cell Cycle | ||||
| miRNA Regulation of DNA Damage Response | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. | |||
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