Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02CZF
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| Former ID |
DIB015737
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| Drug Name |
Aderbasib
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| Synonyms |
INCB-007839; INCB-7839; Sheddase inhibitors (anticancer), Incyte; ADAM inhibitors (oral, cancer), Incyte
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| Drug Type |
Small molecular drug
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| Indication | Breast cancer [ICD-11: 2C60-2C65] | Phase 1/2 | [1] | |
| Company |
Incyte Corp
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| Structure |
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Download2D MOL |
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| Formula |
C21H28N4O5
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| Canonical SMILES |
COC(=O)N1CC2(CC2)CC(C1C(=O)N3CCN(CC3)C4=CC=CC=C4)C(=O)NO
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| InChI |
1S/C21H28N4O5/c1-30-20(28)25-14-21(7-8-21)13-16(18(26)22-29)17(25)19(27)24-11-9-23(10-12-24)15-5-3-2-4-6-15/h2-6,16-17,29H,7-14H2,1H3,(H,22,26)/t16-,17-/m0/s1
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| InChIKey |
DJXMSZSZEIKLQZ-IRXDYDNUSA-N
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| CAS Number |
CAS 791828-58-5
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| PubChem Compound ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT02141451) INCB7839 With Rituximab After Autologous Hematopoietic Cell Transplantation for Diffuse Large B Cell Non-Hodgkin Lymphoma. U.S. National Institutes of Health. | |||
| REF 2 | Company report (Incyte) | |||
| REF 3 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | |||
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