Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02BJB
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| Former ID |
DIB020828
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| Drug Name |
RO116-9132/238
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| Synonyms |
RO116-9132/238; GTPL790; SCHEMBL4958779
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C28H40Cl2N3O4+
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| Canonical SMILES |
CC(C)C(C[N+]1(CCC(CC1)CC2=CC(=C(C=C2)Cl)Cl)C)NC(=O)NC3=CC(=C(C(=C3)OC)OC)OC
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| InChI |
1S/C28H39Cl2N3O4/c1-18(2)24(32-28(34)31-21-15-25(35-4)27(37-6)26(16-21)36-5)17-33(3)11-9-19(10-12-33)13-20-7-8-22(29)23(30)14-20/h7-8,14-16,18-19,24H,9-13,17H2,1-6H3,(H-,31,32,34)/p+1/t19?,24-,33?/m0/s1
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| InChIKey |
INQAQQXKVUWERW-WXJUUJJFSA-O
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | CCR3 messenger RNA (CCR3 mRNA) | Target Info | Antagonist | [2] |
| NetPath Pathway | IL3 Signaling Pathway | |||
| Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 790). | |||
| REF 2 | Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists. Am J Respir Crit Care Med. 2002 Jun 15;165(12):1602-9. | |||
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