Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02AOD
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| Former ID |
DIB003651
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| Drug Name |
HF-0220
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| Synonyms |
Cytoprotective steroid (Alzheimer's disease), Newron; Prostaglandin D synthase stimulator (Alzheimer's disease), Newron; Prostaglandin J2 synthesis stimulator (Alzheimer's disease), Newron; Cytoprotective steroid (Alzheimer's disease), Hunter-Fleming; Prostaglandin D synthase stimulator (Alzheimer's disease), Hunter-Fleming; Prostaglandin J2 synthesis stimulator (Alzheimer's disease), Hunter-Fleming
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| Indication | Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9; ICD-9: 331] | Phase 2 | [1] | |
| Company |
Hunter-Fleming Ltd
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| Structure |
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Download2D MOL |
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| Formula |
C19H30O3
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| Canonical SMILES |
CC12CCC(CC1CC(C3C2CCC4(C3CCC4=O)C)O)O
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| InChI |
1S/C19H30O3/c1-18-7-5-12(20)9-11(18)10-15(21)17-13-3-4-16(22)19(13,2)8-6-14(17)18/h11-15,17,20-21H,3-10H2,1-2H3/t11-,12+,13+,14+,15+,17+,18+,19+/m1/s1
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| InChIKey |
VFPMCLQMAUVEHD-UCPSWNCLSA-N
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| CAS Number |
CAS 25848-69-5
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glutathione-dependent PGD synthase (HPGDS) | Target Info | Stimulator | [2] |
| BioCyc | C20 prostanoid biosynthesis | |||
| KEGG Pathway | Arachidonic acid metabolism | |||
| Metabolic pathways | ||||
| WikiPathways | Arachidonic acid metabolism | |||
| Aryl Hydrocarbon Receptor | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00357357) European Study of HF0220 in Mild to Moderate Alzheimer's Disease Patients. U.S. National Institutes of Health. | |||
| REF 2 | US patent application no. 2009,0062,529, Multi-cyclic compounds. | |||
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