Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D02AMG
|
|||
Former ID |
DIB002329
|
|||
Drug Name |
HGS-1029
|
|||
Synonyms |
AEG-40056; AEG-40057; AEG-40706; AEG-40730; AEG-40826; XIAP antagonists (anticancer), Aegera; Inhibitor of apoptosis (IAP) protein antagonists (cancer), Aegera/HGS; XIAP antagonists (small molecule, cancer), Aegera/HGS; Inhibitory apoptosis protein (IAP) antagonists (apoptosis stimulators, cancer), Aegera/HGS
Click to Show/Hide
|
|||
Indication | Haematological malignancy [ICD-11: 2B33.Y] | Phase 1 | [1] | |
Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Phase 1 | [2] | ||
Company |
Aegera Therapeutics Inc
|
|||
Structure |
Download2D MOL |
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | X-linked inhibitor of apoptosis protein (XIAP) | Target Info | Antagonist | [3] |
KEGG Pathway | NF-kappa B signaling pathway | |||
Ubiquitin mediated proteolysis | ||||
Apoptosis | ||||
Focal adhesion | ||||
Toxoplasmosis | ||||
HTLV-I infection | ||||
Pathways in cancer | ||||
Small cell lung cancer | ||||
Panther Pathway | Apoptosis signaling pathway | |||
Pathway Interaction Database | p75(NTR)-mediated signaling | |||
BMP receptor signaling | ||||
Caspase Cascade in Apoptosis | ||||
TGF-beta receptor signaling | ||||
Reactome | SMAC binds to IAPs | |||
SMAC-mediated dissociation of IAP:caspase complexes | ||||
Deactivation of the beta-catenin transactivating complex | ||||
RIPK1-mediated regulated necrosis | ||||
Regulation of TNFR1 signaling | ||||
TNFR1-induced NFkappaB signaling pathway | ||||
Regulation of necroptotic cell death | ||||
WikiPathways | Copper homeostasis | |||
Focal Adhesion | ||||
Apoptosis | ||||
Intrinsic Pathway for Apoptosis | ||||
Apoptosis Modulation and Signaling | ||||
NOD pathway |
References | Top | |||
---|---|---|---|---|
REF 1 | ClinicalTrials.gov (NCT00708006) A Study of HGS1029 (AEG40826-2HCl) in Subjects With Advanced Solid Tumors. U.S. National Institutes of Health. | |||
REF 2 | Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.Nat Rev Drug Discov. 2016 Aug;15(8):533-50. | |||
REF 3 | Clinical pipeline report, company report or official report of Aegera Therapeutics Inc. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.