Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01YDF
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| Former ID |
DIB015753
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| Drug Name |
Pibutidine
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| Synonyms |
Alex; Pibutidine hydrochloride; IT-066
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| Drug Type |
Small molecular drug
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| Indication | Ulcerative colitis [ICD-11: DD71; ICD-9: 556] | Discontinued in Phase 3 | [1] | |
| Company |
Ikeda Mohando Co Ltd
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| Structure |
 |
Download2D MOL |
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| Formula |
C19H24N4O3
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| Canonical SMILES |
C1CCN(CC1)CC2=CC(=NC=C2)OCC=CCNC3=C(C(=O)C3=O)N
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| InChI |
1S/C19H24N4O3/c20-16-17(19(25)18(16)24)22-7-2-5-11-26-15-12-14(6-8-21-15)13-23-9-3-1-4-10-23/h2,5-6,8,12,22H,1,3-4,7,9-11,13,20H2/b5-2-
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| InChIKey |
XMDYZASWLGWIPL-DJWKRKHSSA-N
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| CAS Number |
CAS 103922-33-4
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:145662
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H2 receptor (H2R) | Target Info | Modulator | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gastric acid secretion | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Histamine H2 receptor mediated signaling pathway | ||||
| Pathwhiz Pathway | Intracellular Signalling Through Histamine H2 Receptor and Histamine | |||
| Gastric Acid Production | ||||
| Reactome | Histamine receptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Secretion of Hydrochloric Acid in Parietal Cells | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000641) | |||
| REF 2 | Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors. Mol Pharmacol. 1995 Oct;48(4):774-82. | |||
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