Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01XNB
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| Former ID |
DAP000180
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| Drug Name |
Omeprazole
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| Synonyms |
Losec (TN)
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| Drug Type |
Small molecular drug
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| Indication | Gastroesophageal reflux disease [ICD-11: DA22.Z] | Approved | [1], [2] | |
| Therapeutic Class |
Antiulcer Agents
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| Company |
AstraZeneca
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| Structure |
 |
Download2D MOL |
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| Formula |
C17H19N3O3S
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| Canonical SMILES |
CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC
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| InChI |
1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
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| InChIKey |
SUBDBMMJDZJVOS-UHFFFAOYSA-N
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| CAS Number |
CAS 73590-58-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9532, 640212, 855576, 3281991, 4696242, 5212304, 7847521, 7980199, 8152819, 10321754, 11112840, 11398365, 11466521, 11467641, 11486042, 11528599, 12013167, 14753960, 14875946, 22391484, 24897870, 26751452, 26751453, 26759296, 29223683, 46386973, 46487906, 46509065, 47365309, 47589088, 47589089, 48035237, 48170542, 48414255, 48416351, 49681572, 49698521, 49834935, 50100529, 50103932, 53788700, 56313300, 56313696, 56313928, 56422106, 57322340, 80295314, 81093370, 85174452, 85788870
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| ChEBI ID |
CHEBI:77260
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| ADReCS Drug ID | BADD_D01614 ; BADD_D01615 | |||
| SuperDrug ATC ID |
A02BC01
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| SuperDrug CAS ID |
cas=073590586
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Alistipes indistinctus DSM22520
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Alistipes indistinctus DSM22520 (log2FC = -2.65; p = 0.0). | |||
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Studied Microbe: Bacteroides
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[4] | |||
| Hierarchy | ||||
| Resulting Metabolite | Sulfide metabolite | |||
| Metabolic Effect | Decrease activity | |||
| Description | Omeprazole can be metabolized to Sulfide metabolite by Bacteroides, which results in the decrease of the drug's activity. | |||
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Studied Microbe: Bacteroides caccae ATCC 43185
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bacteroides caccae ATCC 43185 (log2FC = -6.148; p = 0.005). | |||
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Studied Microbe: Bacteroides cellulosilyticus DSM 14838
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bacteroides cellulosilyticus DSM 14838 (log2FC = -9.851; p = 0.005). | |||
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Studied Microbe: Bacteroides coprophilus DSM 18228
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bacteroides coprophilus DSM 18228 (log2FC = -1.679; p = 0.006). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -10.153; p = 0.005). | |||
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Studied Microbe: Bacteroides eggerthii DSM20697
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bacteroides eggerthii DSM20697 (log2FC = -4.448; p = 0.012). | |||
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Studied Microbe: Bacteroides finegoldii DSM17565
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bacteroides finegoldii DSM17565 (log2FC = -9.513; p = 0.005). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -3.612; p = 0.002). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -3.654; p = 0.003). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -2.87; p = 0.002). | |||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -5.628; p = 0.035). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -3.716; p = 0.013). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -4.531; p = 0.01). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -4.252; p = 0.005). | |||
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Studied Microbe: Bacteroides intestinalis DSM 17393
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bacteroides intestinalis DSM 17393 (log2FC = -5.415; p = 0.019). | |||
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Studied Microbe: Bacteroides ovatus ATCC 8483
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bacteroides ovatus ATCC 8483 (log2FC = -5.419; p = 0.007). | |||
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Studied Microbe: Bacteroides stercoris ATCC 43183
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bacteroides stercoris ATCC 43183 (log2FC = -3.246; p = 0.041). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 3731
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -4.418; p = 0.003). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -3.794; p = 0.004). | |||
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Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -4.421; p = 0.005). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -4.563; p = 0.003). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -10.201; p = 0.005). | |||
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Studied Microbe: Bacteroides WH2
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bacteroides WH2 (log2FC = -4.287; p = 0.045). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -6.499; p = 0.003). | |||
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Studied Microbe: Odoribacter splanchnicus
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Odoribacter splanchnicus (log2FC = -2.212; p = 0.012). | |||
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Studied Microbe: Parabacteroides johnsonii DSM 18315
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Parabacteroides johnsonii DSM 18315 (log2FC = -9.681; p = 0.005). | |||
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Studied Microbe: Parabacteroides merdae ATCC 43184
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Parabacteroides merdae ATCC 43184 (log2FC = -4.364; p = 0.004). | |||
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Studied Microbe: Pretovella copri DSM 18205
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Pretovella copri DSM 18205 (log2FC = -5.097; p = 0.039). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium adolescentis ATCC 15703
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bifidobacterium adolescentis ATCC 15703 (log2FC = -2.855; p = 0.011). | |||
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Studied Microbe: Bifidobacterium breve DSM 20213
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bifidobacterium breve DSM 20213 (log2FC = -5.071; p = 0.023). | |||
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Studied Microbe: Bifidobacterium longum subsp. Infantis CCUG52486
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bifidobacterium longum subsp. Infantis CCUG52486 (log2FC = -3.396; p = 0.004). | |||
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Studied Microbe: Bifidobacterium ruminantium
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bifidobacterium ruminantium (log2FC = -4.067; p = 0.015). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
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Studied Microbe: Collinsella aerofaciens ATCC25986
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Collinsella aerofaciens ATCC25986 (log2FC = -9.659; p = 0.005). | |||
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Studied Microbe: Collinsella intestinalis DSM 13280
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Collinsella intestinalis DSM 13280 (log2FC = -2.786; p = 0.005). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
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Studied Microbe: Eggerthella lenta ATCC 25559
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Eggerthella lenta ATCC 25559 (log2FC = -2.207; p = 0.009). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Edwardsiella tarda ATCC 23685
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Edwardsiella tarda ATCC 23685 (log2FC = -9.65; p = 0.005). | |||
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Studied Microbe: Enterobacter cancerogenus ATCC35316
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Enterobacter cancerogenus ATCC35316 (log2FC = -9.2; p = 0.005). | |||
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Studied Microbe: Escherichia coli BW25113
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Escherichia coli BW25113 (log2FC = -2.706; p = 0.016). | |||
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Studied Microbe: Proteus penneri ATCC 35198
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Proteus penneri ATCC 35198 (log2FC = -9.316; p = 0.005). | |||
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Studied Microbe: Providencia alcalifaciens DSM 30120
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Providencia alcalifaciens DSM 30120 (log2FC = -2.804; p = 0.019). | |||
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Studied Microbe: Providencia rettgeri DSM 1131
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Providencia rettgeri DSM 1131 (log2FC = -3.496; p = 0.017). | |||
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Studied Microbe: Providencia stuartii ATCC 25827
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Providencia stuartii ATCC 25827 (log2FC = -9.427; p = 0.005). | |||
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Studied Microbe: Salmonella typhimurium LT2
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Salmonella typhimurium LT2 (log2FC = -2.222; p = 0.003). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Clostridium ramosum DSM 1402
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Clostridium ramosum DSM 1402 (log2FC = -5.802; p = 0.006). | |||
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Studied Microbe: Clostridium spiroforme DSM1552
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Clostridium spiroforme DSM1552 (log2FC = -9.436; p = 0.005). | |||
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Studied Microbe: Eubacterium biforme DSM 3989
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Eubacterium biforme DSM 3989 (log2FC = -1.944; p = 0.013). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Anaerostipes sp.
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Anaerostipes sp. (log2FC = -9.667; p = 0.005). | |||
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Studied Microbe: Anaerotruncus colihominis DSM 17241
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Anaerotruncus colihominis DSM 17241 (log2FC = -8.986; p = 0.005). | |||
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Studied Microbe: Bacteroides pectinophilus ATCC 43243
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bacteroides pectinophilus ATCC 43243 (log2FC = -6.481; p = 0.005). | |||
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Studied Microbe: Blautia hansenii DSM20583
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Blautia hansenii DSM20583 (log2FC = -3.162; p = 0.012). | |||
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Studied Microbe: Blautia luti DSM 14534
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Blautia luti DSM 14534 (log2FC = -3.449; p = 0.006). | |||
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Studied Microbe: Bryantia formatexigens DSM 14469
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Bryantia formatexigens DSM 14469 (log2FC = -1.814; p = 0.001). | |||
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Studied Microbe: Clostridium asparagiforme DSM 15981
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Clostridium asparagiforme DSM 15981 (log2FC = -2.775; p = 0.036). | |||
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Studied Microbe: Clostridium difficile 120
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Clostridium difficile 120 (log2FC = -2.527; p = 0.002). | |||
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Studied Microbe: Clostridium hathewayi DSM 13479
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Clostridium hathewayi DSM 13479 (log2FC = -9.61; p = 0.005). | |||
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Studied Microbe: Clostridium scindens ATCC 35704
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Clostridium scindens ATCC 35704 (log2FC = -9.492; p = 0.005). | |||
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Studied Microbe: Clostridium sp.
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Clostridium sp. (log2FC = -3.005; p = 0.006). | |||
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Studied Microbe: Clostridium sporogenes ATCC 15579
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Clostridium sporogenes ATCC 15579 (log2FC = -1.987; p = 0.006). | |||
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Studied Microbe: Clostridium symbiosum ATCC 14940
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Clostridium symbiosum ATCC 14940 (log2FC = -9.773; p = 0.005). | |||
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Studied Microbe: Coprococcus comes ATCC 27758
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Coprococcus comes ATCC 27758 (log2FC = -5.503; p = 0.004). | |||
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Studied Microbe: Dorea formicigenerans ATCC 27755
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Dorea formicigenerans ATCC 27755 (log2FC = -9.463; p = 0.005). | |||
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Studied Microbe: Enterocloster bolteae ATCC BAA-613
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Enterocloster bolteae ATCC BAA-613 (log2FC = -9.578; p = 0.005). | |||
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Studied Microbe: Eubacterium hallii DSM3353
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Eubacterium hallii DSM3353 (log2FC = -1.67; p = 0.006). | |||
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Studied Microbe: Eubacterium rectale ATCC 33656
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Eubacterium rectale ATCC 33656 (log2FC = -2.319; p = 0.004). | |||
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Studied Microbe: Eubacterium ventriosum ATCC 27560
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Eubacterium ventriosum ATCC 27560 (log2FC = -9.467; p = 0.005). | |||
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Studied Microbe: Roseburia intestinalis L1-82
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Roseburia intestinalis L1-82 (log2FC = -2.045; p = 0.002). | |||
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Studied Microbe: Ruminococcus gnavus ATCC 29149
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Ruminococcus gnavus ATCC 29149 (log2FC = -2.718; p = 0.008). | |||
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Studied Microbe: Ruminococcus lactaris ATCC 29176
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Ruminococcus lactaris ATCC 29176 (log2FC = -9.362; p = 0.005). | |||
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Studied Microbe: Ruminococcus torques ATCC 27756
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Ruminococcus torques ATCC 27756 (log2FC = -1.764; p = 0.004). | |||
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Studied Microbe: Subdoligranulum variabile DSM 15176
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Subdoligranulum variabile DSM 15176 (log2FC = -2.391; p = 0.006). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Enterococcus faecalis V583
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Enterococcus faecalis V583 (log2FC = -4.875; p = 0.002). | |||
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Studied Microbe: Lactobacillus reuteri CF48-3A
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Lactobacillus reuteri CF48-3A (log2FC = -2.014; p = 0.012). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Tissierellales | ||||
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Studied Microbe: Anaerococcus hydrogenalis DSM 7454
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Anaerococcus hydrogenalis DSM 7454 (log2FC = -9.892; p = 0.005). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
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Studied Microbe: Akkermansia muciniphila ATCC BAA-835
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Akkermansia muciniphila ATCC BAA-835 (log2FC = -1.917; p = 0.027). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Victivallales | ||||
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Studied Microbe: Victivallis vadensis ATCC BAA-548
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Omeprazole can be metabolized by Victivallis vadensis ATCC BAA-548 (log2FC = -1.66; p = 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
| Studied Microbe: Anaerobic bacterium unspecific | [5] | |||
| Metabolic Reaction | Reduction | |||
| Resulting Metabolite | Sulfide metabolite | |||
| Metabolic Effect | Decrease activity | |||
| Description | Omeprazole can be metabolized to Sulfide metabolite by unspecific Anaerobic bacterium through reduction, which results in the decrease of the drug's activity. | |||
| Studied Microbe: Gut microbiota unspecific | [6], [7] | |||
| Metabolic Reaction | Sulfoxide reduction | |||
| Resulting Metabolite | Sulfide metabolite | |||
| Metabolic Effect | Increase activity | |||
| Description | Omeprazole can be metabolized to Sulfide metabolite by gut microbiota through sulfoxide reduction, which results in the increase of the drug's activity. | |||
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides
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[8] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Bacteroides was decreased by Combination of omeprazole, clarithromycin and metronidazole. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium
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[8] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Bifidobacterium was decreased by Combination of omeprazole, clarithromycin and metronidazole. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Citrobacter
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[8] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Citrobacter was increased by Combination of omeprazole, amoxicillin and metronidazole. | |||
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Studied Microbe: Enterobacteriaceae
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[8] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Enterobacteriaceae was increased by Combination of omeprazole, amoxicillin and metronidazole. | |||
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Studied Microbe: Klebsiella
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[8] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Klebsiella was increased by Combination of omeprazole, amoxicillin and metronidazole. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia obeum
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[9] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Blautia obeum was decreased by Omeprazole (adjusted p-values: 1.90E-06). | |||
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Studied Microbe: Clostridium
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[8] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Clostridium was decreased by Combination of omeprazole, clarithromycin and metronidazole. | |||
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Studied Microbe: Clostridium difficile
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[8] | |||
| Hierarchy | ||||
| Abundance Change | No significant change | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Clostridium difficile was not significantly changed by Combination of omeprazole, clarithromycin and metronidazole. | |||
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Studied Microbe: Dorea formicigenerans
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[9] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Dorea formicigenerans was decreased by Omeprazole (adjusted p-values: 1.32E-05). | |||
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Studied Microbe: Eubacterium eligens
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[9] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium eligens was decreased by Omeprazole (adjusted p-values: 4.28E-03). | |||
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Studied Microbe: Eubacterium rectale
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[9] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium rectale was decreased by Omeprazole (adjusted p-values: 6.47E-03). | |||
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Studied Microbe: Peptostreptococcus
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[8] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Peptostreptococcus was increased by Combination of omeprazole, amoxicillin and metronidazole. | |||
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Studied Microbe: Peptostreptococcus
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[8] | |||
| Hierarchy | ||||
| Abundance Change | No significant change | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Peptostreptococcus was not significantly changed by Combination of omeprazole, clarithromycin and metronidazole. | |||
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Studied Microbe: Roseburia intestinalis
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[9] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia intestinalis was decreased by Omeprazole (adjusted p-values: 7.50E-04). | |||
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Studied Microbe: Ruminococcus bromii
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[9] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus bromii was decreased by Omeprazole (adjusted p-values: 1.97E-04). | |||
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Studied Microbe: Ruminococcus torques
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[9] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus torques was decreased by Omeprazole (adjusted p-values: 4.29E-05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Enterococcus
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[8] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Enterococcus was increased by Combination of omeprazole, amoxicillin and metronidazole. | |||
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Studied Microbe: Enterococcus
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[8] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Enterococcus was increased by Combination of omeprazole, clarithromycin and metronidazole. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Veillonellales | ||||
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Studied Microbe: Veillonella
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[8] | |||
| Hierarchy | ||||
| Abundance Change | No significant change | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Veillonella was not significantly changed by Combination of omeprazole, clarithromycin and metronidazole. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
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Studied Microbe: Actinomycetales
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[10] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Actinomycetales was increased by Omeprazole (p < 0.05). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Gastric H(+)/K(+) ATPase (Proton pump) | Target Info | Modulator | [11] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4279). | |||
| REF 2 | Generic omeprazole delayed-release capsules: in vitro performance evaluations. Drug Dev Ind Pharm. 2009 Aug;35(8):917-21. | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 4 | Gut microbiota: what is its place in pharmacology?. Expert Rev Clin Pharmacol. 2019 Oct;12(10):921-930. | |||
| REF 5 | The influence of gut microbiota on drug metabolism and toxicity. Expert Opin Drug Metab Toxicol. 2016;12(1):31-40. | |||
| REF 6 | Human gut microbiota plays a role in the metabolism of drugs. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016 Sep;160(3):317-26. | |||
| REF 7 | Metabolism of omeprazole by gut flora in rats. J Pharm Sci. 1995 Apr;84(4):516-7. | |||
| REF 8 | Comparative effects of omeprazole, amoxycillin plus metronidazole versus omeprazole, clarithromycin plus metronidazole on the oral, gastric and intestinal microflora in Helicobacter pylori-infected patients. J Antimicrob Chemother. 1999 Nov;44(5):629-40. | |||
| REF 9 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 10 | Celiac disease serology and gut microbiome following proton pump inhibitor treatment. Medicine (Baltimore). 2020 Aug 28;99(35):e21488. | |||
| REF 11 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
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