Drug Information
Drug General Information | Top | |||
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Drug ID |
D01WWK
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Former ID |
DIB018079
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Drug Name |
(2E, 6E)-farnesylbisphosphonate
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Synonyms |
(2E, 6E)-farnesylbisphosphonate; GTPL3200; SCHEMBL8916061; SCHEMBL2875241; (e,e)-(4,8,12-trimethyl-3,7,11-tridecatrienylidene)bisphosphonic acid; [(3E,7E)-4,8,12-trimethyl-1-phosphonotrideca-3,7,11-trien-1-yl]phosphonic acid
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C16H30O6P2
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Canonical SMILES |
CC(=CCCC(=CCCC(=CCC(P(=O)(O)O)P(=O)(O)O)C)C)C
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InChI |
1S/C16H30O6P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-16(23(17,18)19)24(20,21)22/h7,9,11,16H,5-6,8,10,12H2,1-4H3,(H2,17,18,19)(H2,20,21,22)/b14-9+,15-11+
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InChIKey |
QBAOBDKNTDWTHR-YFVJMOTDSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Geranyltranstransferase (FDPS) | Target Info | Inhibitor | [2] |
BioCyc | Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) | |||
Superpathway of cholesterol biosynthesis | ||||
Trans, trans-farnesyl diphosphate biosynthesis | ||||
Geranylgeranyldiphosphate biosynthesis | ||||
KEGG Pathway | Terpenoid backbone biosynthesis | |||
Metabolic pathways | ||||
Biosynthesis of antibiotics | ||||
Influenza A | ||||
HTLV-I infection | ||||
NetPath Pathway | TCR Signaling Pathway | |||
Panther Pathway | Cholesterol biosynthesis | |||
Pathwhiz Pathway | Steroid Biosynthesis | |||
Reactome | Cholesterol biosynthesis | |||
Activation of gene expression by SREBF (SREBP) | ||||
WikiPathways | Activation of Gene Expression by SREBP (SREBF) | |||
SREBP signalling | ||||
Cholesterol Biosynthesis |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3200). | |||
REF 2 | Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors. Bioorg Med Chem. 2008 Jan 1;16(1):390-9. |
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