Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01UUD
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| Former ID |
DNCL003130
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| Drug Name |
Pitolisant
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| Synonyms |
Pitolisant; 362665-56-3; TIPROLISANT; BF2.649; UNII-4BC83L4PIY; 1-[3-[3-(4-chlorophenyl)propoxy]propyl]piperidine; Pitolisant (BF2.649); 1-(3-(3-(4-Chlorophenyl)propoxy)propyl)piperidine; 4BC83L4PIY; Piperidine, 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-; CHEMBL462605; wakix; 1-[3-[3-(4-Chlorophenyl)propoxy]propyl]-piperidinehydrochloride; 1-{3-[3-(4-chlorophenyl)propoxy]propyl}piperidine; Tirolisant; Pitolisant (INN); tiprolisant [USAN]; Wakix (TN); Pitolisant [USAN:INN]; SCHEMBL117648; GTPL8924; CTK1B6404; HBS-101
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| Drug Type |
Small molecular drug
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| Indication | Excessive daytime sleepiness [ICD-11: MG42; ICD-10: F51.1, G47.1] | Approved | [1] | |
| Schizophrenia [ICD-11: 6A20] | Phase 3 | [2] | ||
| Company |
Bioprojet; Ferrer
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| Structure |
 |
Download2D MOL |
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| Formula |
C17H26ClNO
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| Canonical SMILES |
C1CCN(CC1)CCCOCCCC2=CC=C(C=C2)Cl
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| InChI |
1S/C17H26ClNO/c18-17-9-7-16(8-10-17)6-4-14-20-15-5-13-19-11-2-1-3-12-19/h7-10H,1-6,11-15H2
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| InChIKey |
NNACHAUCXXVJSP-UHFFFAOYSA-N
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| CAS Number |
CAS 362665-56-3
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:134709
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H3 receptor (H3R) | Target Info | Agonist | [1] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Histamine receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Monoamine Transport | |||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 | |||
| REF 2 | ClinicalTrials.gov (NCT01800045) Pitolisant to Assess Weekly Frequency of Cataplexy Attacks and EDS in Narcoleptic Patients (HARMONY CTP). U.S. National Institutes of Health. | |||
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