Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01TGE
|
|||
| Drug Name |
Heterocycle-containing compound 2
|
|||
| Synonyms |
PMID25828189-Compound-14
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Company |
PFIZER INC. ASPNES, Gary, Erik DIDIUK, Mary, Theresa FILIPSKI, Kevin, James GUZMAN-PEREZ, Angel PFEFFERKORN, Jeffrey, Allen STEVENS, Benjamin, Dawson TU, Meihua, Mik
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C28H28F3NO4
|
|||
| Canonical SMILES |
CC(C)CC(C1=CC=C(C=C1)C(=O)NCCC(=O)O)OC2=CC=C(C=C2)C3=CC=C(C=C3)C(F)(F)F
|
|||
| InChI |
1S/C28H28F3NO4/c1-18(2)17-25(21-3-5-22(6-4-21)27(35)32-16-15-26(33)34)36-24-13-9-20(10-14-24)19-7-11-23(12-8-19)28(29,30)31/h3-14,18,25H,15-17H2,1-2H3,(H,32,35)(H,33,34)
|
|||
| InChIKey |
KVQXZASOMKRHSG-UHFFFAOYSA-N
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glucagon receptor (GCGR) | Target Info | Antagonist | [1] |
| Target's Patent Info | Glucagon receptor (GCGR) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Glucagon signaling pathway | ||||
| Reactome | Glucagon signaling in metabolic regulation | |||
| G alpha (q) signalling events | ||||
| G alpha (s) signalling events | ||||
| Glucagon-type ligand receptors | ||||
| WikiPathways | GPCRs, Class B Secretin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Integration of energy metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.