Drug Information
Drug General Information | Top | |||
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Drug ID |
D01SRL
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Former ID |
DNC004985
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Drug Name |
7-Nitro-1,2,3,4-tetrahydro-isoquinoline
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Synonyms |
7-Nitro-1,2,3,4-tetrahydroisoquinoline; 42923-79-5; 7-Nitro-1,2,3,4-tetrahydro-isoquinoline; 1,2,3,4-Tetrahydro-7-nitroisoquinoline; CHEMBL281289; YPRWYZSUBZXORL-UHFFFAOYSA-N; ISOQUINOLINE, 1,2,3,4-TETRAHYDRO-7-NITRO-; N90100; 7-nitrotetrahydroisoquinoline; SCHEMBL324460; 7-Nitro-tetrahydroisoquinoline; AC1O502M; SCHEMBL10066165; CTK4I6796; DTXSID30423728; MolPort-003-886-230; BCP09681; KS-00000DK2; ACT10738; CS-D0150; ANW-50594; ZINC13686846; BDBM50072991; AKOS005259136; QC-5046; AB21318; RP03102; MCULE-4384372233; AC-9598
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C9H10N2O2
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Canonical SMILES |
C1CNCC2=C1C=CC(=C2)[N+](=O)[O-]
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InChI |
1S/C9H10N2O2/c12-11(13)9-2-1-7-3-4-10-6-8(7)5-9/h1-2,5,10H,3-4,6H2
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InChIKey |
YPRWYZSUBZXORL-UHFFFAOYSA-N
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CAS Number |
CAS 42923-79-5
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Adrenergic receptor alpha-2A (ADRA2A) | Target Info | Inhibitor | [1] |
KEGG Pathway | cGMP-PKG signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Panther Pathway | Alpha adrenergic receptor signaling pathway | |||
Reactome | Adrenoceptors | |||
Adrenaline signalling through Alpha-2 adrenergic receptor | ||||
Adrenaline,noradrenaline inhibits insulin secretion | ||||
G alpha (i) signalling events | ||||
G alpha (z) signalling events | ||||
Surfactant metabolism | ||||
WikiPathways | Monoamine GPCRs | |||
GPCRs, Class A Rhodopsin-like | ||||
Platelet Aggregation (Plug Formation) | ||||
Integration of energy metabolism | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoqui... Bioorg Med Chem Lett. 2005 Feb 15;15(4):1143-7. |
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