Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01RAD
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| Former ID |
DNC000278
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| Drug Name |
Bay K 8644
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| Synonyms |
71145-03-4; methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate; MLS000028858; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, methyl ester; C16H15F3N2O4; R(+)-BAY K 8644; SMR000058424; Methyl 2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylate
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C16H15F3N2O4
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| Canonical SMILES |
CC1=C(C(C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC
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| InChI |
1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3
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| InChIKey |
ZFLWDHHVRRZMEI-UHFFFAOYSA-N
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| CAS Number |
CAS 71145-03-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
586344, 3153116, 5612003, 7978758, 8151543, 11119911, 11120399, 11120887, 11146994, 11532945, 12012612, 14876535, 17404749, 24277825, 26752215, 26752216, 26758290, 29221473, 47515050, 47959444, 48034823, 49635693, 49738153, 50065424, 50068111, 50104893, 50104894, 50104895, 53777292, 53789951, 53801066, 56422388, 56462966, 57321241, 76625027, 85084036, 85084037, 85230929, 85787709, 90341659, 91746258, 92303551, 92309994, 99300906, 103756939, 103828780, 103941888, 103943741, 104300195, 117557928
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| ChEBI ID |
CHEBI:34555
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Voltage-gated L-type calcium channel (L-CaC) | Target Info | Activator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2511). | |||
| REF 2 | Molecular determinants of drug binding and action on L-type calcium channels. Annu Rev Pharmacol Toxicol. 1997;37:361-96. | |||
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