Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01OUE
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| Former ID |
DAP001081
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| Drug Name |
Betazole
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| Synonyms |
Ametazole; Betazol; Betazolo; Betazolum; Betazole [INN]; Betazolo [DCIT]; Lilly 96791; Betazol [INN-Spanish]; Betazolum [INN-Latin]; 1H-Pyrazole-3-ethanamine; 2-(1H-Pyrazol-3-yl)ethanamine; 2-(1H-pyrazol-5-yl)ethanamine; 2-(3-Pyrazolyl)ethylamine; 3-(2-Aminoethyl)pyrazole; 3-(beta-aminoethyl)pyrazole
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| Drug Type |
Small molecular drug
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| Indication | Gastric secretory disorder [ICD-11: DD90; ICD-10: K30; ICD-9: 536.8] | Approved | [1], [2] | |
| Therapeutic Class |
Antihistamines
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| Company |
Eli Lilly And Co
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| Structure |
 |
Download2D MOL |
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| Formula |
C5H9N3
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| Canonical SMILES |
C1=C(NN=C1)CCN
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| InChI |
1S/C5H9N3/c6-3-1-5-2-4-7-8-5/h2,4H,1,3,6H2,(H,7,8)
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| InChIKey |
JXDFEQONERDKSS-UHFFFAOYSA-N
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| CAS Number |
CAS 105-20-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
6945788, 10503079, 11112911, 11466071, 11467191, 11485822, 15066099, 17296723, 29226545, 46506808, 47943903, 47943904, 48169506, 48169507, 48415635, 49699357, 50064104, 50100538, 50759200, 57324449, 85209542, 88830371, 92741766, 103813928, 104315840, 117521710, 123083201, 125676860, 126604015, 128340252, 128340253, 131645124, 134338338, 134970986, 137006888, 137125827, 143503545, 145520280, 160963620, 162477057, 170527099, 172869629, 176243402, 178103703, 179225281, 186016280, 198968267, 223518983, 224984500, 225228099
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| ChEBI ID |
CHEBI:59170
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| SuperDrug ATC ID |
V04CG02
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| SuperDrug CAS ID |
cas=000105204
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H2 receptor (H2R) | Target Info | Antagonist | [3] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gastric acid secretion | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Histamine H2 receptor mediated signaling pathway | ||||
| Pathwhiz Pathway | Intracellular Signalling Through Histamine H2 Receptor and Histamine | |||
| Gastric Acid Production | ||||
| Reactome | Histamine receptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Secretion of Hydrochloric Acid in Parietal Cells | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7126). | |||
| REF 2 | Drug information of Betazole, 2008. eduDrugs. | |||
| REF 3 | Effect of nizatidine and cimetidine on betazole-stimulated gastric secretion of normal subjects: comparison of effects on acid, water, and pepsin. Am J Gastroenterol. 1988 Jan;83(1):32-6. | |||
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