Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01NIR
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| Former ID |
DIB007414
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| Drug Name |
Radotinib
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| Synonyms |
IY-5511; IY-GV50205; Anticancer, Il-yang
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| Drug Type |
Small molecular drug
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| Indication | leukaemia [ICD-11: 2A60-2B33; ICD-9: 208.9] | Phase 3 | [1], [2] | |
| Company |
Il-Yang Pharmaceutical Co
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| Structure |
 |
Download2D MOL |
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| Formula |
C27H21F3N8O
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| Canonical SMILES |
CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3C=C(N=C3)C)NC4=NC=CC(=N4)C5=NC=CN=C5
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| InChI |
1S/C27H21F3N8O/c1-16-3-4-18(9-23(16)37-26-33-6-5-22(36-26)24-13-31-7-8-32-24)25(39)35-20-10-19(27(28,29)30)11-21(12-20)38-14-17(2)34-15-38/h3-15H,1-2H3,(H,35,39)(H,33,36,37)
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| InChIKey |
DUPWHXBITIZIKZ-UHFFFAOYSA-N
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| CAS Number |
CAS 926037-48-1
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Fusion protein Bcr-Abl (Bcr-Abl) | Target Info | Modulator | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7814). | |||
| REF 2 | ClinicalTrials.gov (NCT01511289) Radotinib Versus Imatinib in Newly Diagnosed Philadelphia Chromosome and Chronic Myeloid Leukemia Chronic Phase Patients. U.S. National Institutes of Health. | |||
| REF 3 | Danusertib, an aurora kinase inhibitor.Expert Opin Investig Drugs.2012 Mar;21(3):383-93. | |||
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