Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01MFT
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| Former ID |
DIB019125
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| Drug Name |
chlordane
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| Synonyms |
Chlorindan; chlordan
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C10H6Cl8
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| Canonical SMILES |
C1C2C(C(C1Cl)Cl)C3(C(=C(C2(C3(Cl)Cl)Cl)Cl)Cl)Cl
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| InChI |
1S/C10H6Cl8/c11-3-1-2-4(5(3)12)9(16)7(14)6(13)8(2,15)10(9,17)18/h2-5H,1H2
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| InChIKey |
BIWJNBZANLAXMG-UHFFFAOYSA-N
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| CAS Number |
CAS 57-74-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
74545, 5990793, 7846988, 8153727, 10524652, 10524654, 10528035, 15254259, 17389114, 24868853, 26675693, 29225008, 49833602, 49854452, 49854892, 49991946, 49991954, 53788767, 57323100, 57650320, 79281392, 103469382, 103841549, 104310809, 117452566, 124890903, 127522119, 135073641, 135650085, 137003041, 141047671, 144207488, 163133498, 163359514, 164788171, 176254526, 176256193, 176256195, 176269023, 184546714, 184548134, 184548135, 226455461, 250126803, 252402033
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| ChEBI ID |
CHEBI:34623
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Estrogen-related receptor-alpha (ESRRA) | Target Info | Antagonist | [2] |
| Reactome | PPARA activates gene expression | |||
| Transcriptional activation of mitochondrial biogenesis | ||||
| Nuclear Receptor transcription pathway | ||||
| WikiPathways | Mitochondrial Gene Expression | |||
| Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2831). | |||
| REF 2 | Two organochlorine pesticides, toxaphene and chlordane, are antagonists for estrogen-related receptor alpha-1 orphan receptor. Cancer Res. 1999 Sep 15;59(18):4519-24. | |||
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