Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01LXD
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| Former ID |
DIB015876
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| Drug Name |
Semagacestat
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| Synonyms |
DAPT; AN-37124; AN-44989; LY-374973; LY-411575; LY-424354; LY-450139; LY-4501395; Gamma-secretase inhibitors (Alzheimer's disease), Elan Pharmaceuticals/Eli Lilly
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| Drug Type |
Small molecular drug
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| Indication | Parkinson disease [ICD-11: 8A00.0; ICD-9: 332] | Phase 3 | [1], [2] | |
| Company |
Eli Lilly & Co
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| Structure |
 |
Download2D MOL |
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| Formula |
C19H27N3O4
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| Canonical SMILES |
CC(C)C(C(=O)NC(C)C(=O)NC1C2=CC=CC=C2CCN(C1=O)C)O
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| InChI |
1S/C19H27N3O4/c1-11(2)16(23)18(25)20-12(3)17(24)21-15-14-8-6-5-7-13(14)9-10-22(4)19(15)26/h5-8,11-12,15-16,23H,9-10H2,1-4H3,(H,20,25)(H,21,24)/t12-,15-,16-/m0/s1
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| InChIKey |
PKXWXXPNHIWQHW-RCBQFDQVSA-N
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| CAS Number |
CAS 425386-60-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
14852546, 15298679, 24141417, 44941822, 56310608, 58098132, 75205756, 76715574, 93619014, 96026057, 103584279, 104253240, 118050330, 123051050, 124757363, 125164167, 126596747, 126647846, 126671457, 126731355, 135253081, 135263921, 136348262, 136367557, 136367887, 137164588, 141908225, 143497999, 144116177, 152063993, 152164535, 152236436, 152258054, 152344379, 160646892, 162011753, 162037681, 162114365, 162202739, 163108946, 164044680, 164194128, 164210341, 164834023, 170558965, 174006702, 174529363, 178103557, 184823811, 188900006
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| ChEBI ID |
CHEBI:131158
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6978). | |||
| REF 2 | ClinicalTrials.gov (NCT01035138) A Study of Semagacestat for Alzheimer's Patients. U.S. National Institutes of Health. | |||
| REF 3 | A phase 3 trial of semagacestat for treatment of Alzheimer's disease. N Engl J Med. 2013 Jul 25;369(4):341-50. | |||
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