Drug Information
Drug General Information | Top | |||
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Drug ID |
D01LKO
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Former ID |
DNC008573
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Drug Name |
WFwGG-NH2
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Synonyms |
CHEMBL444131; wFwGG-NH2
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C35H38N8O5
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Canonical SMILES |
C1=CC=C(C=C1)CC(C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC(=O)NCC(=O)N)NC(=O)C(CC4=CNC5=CC=CC=C54)N
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InChI |
1S/C35H38N8O5/c36-26(15-22-17-38-27-12-6-4-10-24(22)27)33(46)42-29(14-21-8-2-1-3-9-21)35(48)43-30(34(47)41-20-32(45)40-19-31(37)44)16-23-18-39-28-13-7-5-11-25(23)28/h1-13,17-18,26,29-30,38-39H,14-16,19-20,36H2,(H2,37,44)(H,40,45)(H,41,47)(H,42,46)(H,43,48)/t26-,29+,30-/m1/s1
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InChIKey |
WIJADCOBFJYNSF-JJZPZGAKSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Growth hormone secretagogue receptor 1 (GHSR) | Target Info | Inhibitor | [1] |
KEGG Pathway | cAMP signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
NetPath Pathway | Leptin Signaling Pathway | |||
Reactome | Peptide ligand-binding receptors | |||
G alpha (q) signalling events | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
Peptide GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism. J Biol Chem. 2007 May 25;282(21):15799-811. |
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