Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01JOJ
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| Former ID |
DIB000500
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| Drug Name |
RX-77368
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| Synonyms |
TRH analog, Reckitt & Colman
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| Drug Type |
Small molecular drug
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| Indication | Dementia [ICD-11: 6D80-6D86] | Discontinued in Phase 2 | [1] | |
| Company |
Reckitt; Colman plc
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| Structure |
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Download2D MOL |
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| Formula |
C18H26N6O4
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| Canonical SMILES |
CC1(CCN(C1C(=O)N)C(=O)C(CC2=CN=CN2)NC(=O)C3CCC(=O)N3)C
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| InChI |
1S/C18H26N6O4/c1-18(2)5-6-24(14(18)15(19)26)17(28)12(7-10-8-20-9-21-10)23-16(27)11-3-4-13(25)22-11/h8-9,11-12,14H,3-7H2,1-2H3,(H2,19,26)(H,20,21)(H,22,25)(H,23,27)/t11-,12-,14+/m0/s1
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| InChIKey |
ZEQAPQNFHVYDEL-SGMGOOAPSA-N
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| CAS Number |
CAS 76820-40-1
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Thyrotropin-releasing hormone (TRH) | Target Info | Modulator | [2], [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001316) | |||
| REF 2 | Intracisternal urocortin inhibits vagally stimulated gastric motility in rats: role of CRF(2).Br J Pharmacol.2002 May;136(2):237-47. | |||
| REF 3 | Thyrotropin releasing hormone (TRH) and a degradation stabilized analogue (RX77368) stimulate phosphoinositide turnover in cultured astrocytes in a... Neurochem Int. 1992 Apr;20(3):307-13. | |||
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