Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01JEU
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| Former ID |
DIB003515
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| Drug Name |
Memantine
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| Synonyms |
Memantine ER; Namenda XR; Memantine (extended release); Memantine (extended release), Forest
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| Drug Type |
Small molecular drug
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| Indication | Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9; ICD-9: 331] | Approved | [1], [2] | |
| Company |
Merz & Co GmbH
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| Structure |
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Download2D MOL |
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| Formula |
C12H21N
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| Canonical SMILES |
CC12CC3CC(C1)(CC(C3)(C2)N)C
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| InChI |
1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3
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| InChIKey |
BUGYDGFZZOZRHP-UHFFFAOYSA-N
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| CAS Number |
CAS 19982-08-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
586325, 598200, 3221249, 6380039, 7737264, 8149719, 8152542, 11167042, 11335243, 11360482, 11363501, 11366063, 11368625, 11372025, 11374681, 11376787, 11461454, 11467006, 11468126, 11485192, 11486662, 11489224, 11490738, 11492836, 11494421, 15147301, 24310548, 26751885, 29223165, 46506702, 47290972, 47290973, 47440080, 47515155, 47662108, 47736297, 47736298, 48184834, 48259056, 48334316, 49698917, 50057972, 50104569, 53790630, 57322117, 74530305, 90341818, 96024864, 99301156, 103211988
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| ChEBI ID |
CHEBI:64312
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| ADReCS Drug ID | BADD_D01378 ; BADD_D01379 | |||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium ruminantium
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Memantine can be metabolized by Bifidobacterium ruminantium (log2FC = -0.419; p = 0.047). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Eubacterium biforme DSM 3989
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Memantine can be metabolized by Eubacterium biforme DSM 3989 (log2FC = -0.329; p = 0.046). | |||
| Drug Resistance Mutation (DRM) | Top | |||
|---|---|---|---|---|
| DRM | DRM Info | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | N-methyl-D-aspartate receptor (NMDAR) | Target Info | Modulator | [4], [5] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4253). | |||
| REF 2 | Treatment effect size of memantine therapy in Alzheimer disease and vascular dementia. Alzheimer Dis Assoc Disord. 2006 Jul-Sep;20(3):133-7. | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 4 | The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: preclinical evidence. Int J Geriatr Psychiatry. 2003 Sep;18(Suppl 1):S23-32. | |||
| REF 5 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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