Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01IXD
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| Former ID |
DIB015415
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| Drug Name |
Finafloxacin
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| Synonyms |
Finafloxacin hydrochloride; Antibacterial (Helicobacter pylori infection/ bacterial urinary tract infection), Combinature; Finafloxacin (iv, bacterial infection), MerLion/Alcon; Finafloxacin (oral, bacterial infection), MerLion/Alcon
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| Drug Type |
Small molecular drug
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| Indication | Urinary tract infection [ICD-11: GC08; ICD-10: N39, N39.0; ICD-9: 599] | Approved | [1], [2] | |
| Company |
Alcon
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| Structure |
 |
Download2D MOL |
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| Formula |
C20H19FN4O4
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| Canonical SMILES |
C1CC1N2C=C(C(=O)C3=CC(=C(C(=C32)C#N)N4CC5C(C4)OCCN5)F)C(=O)O
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| InChI |
1S/C20H19FN4O4/c21-14-5-11-17(25(10-1-2-10)7-13(19(11)26)20(27)28)12(6-22)18(14)24-8-15-16(9-24)29-4-3-23-15/h5,7,10,15-16,23H,1-4,8-9H2,(H,27,28)/t15-,16-/m0/s1
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| InChIKey |
FYMHQCNFKNMJAV-HOTGVXAUSA-N
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| CAS Number |
CAS 209342-40-5
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:85176
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bacterial DNA gyrase (Bact gyrase) | Target Info | Modulator | [1], [3] |
| Staphylococcus Topoisomerase IV (Stap-coc parC) | Target Info | Modulator | [1], [3] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. | |||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 3 | Antibacterial activity of finafloxacin under different pH conditions against isogenic strains of Escherichia coli expressing combinations of defined mechanisms of fluoroquinolone resistance.J Antimicrob Chemother.2010 Dec;65(12):2530-3. | |||
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