Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01IRG
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| Drug Name |
Bictegravir, emtricitabine and tenofovir alafenamide
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| Synonyms |
S900007760; Bictegravir mixture with emtricitabine and tenofovir alafenamide
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| Indication | Human immunodeficiency virus infection [ICD-11: 1C62; ICD-9: 42] | Approved | [1] | |
| Company |
Gilead Sciences
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| Structure |
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Download2D MOL |
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| Formula |
C50H57F4N12O13PS
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| Canonical SMILES |
CC(C)OC(=O)C(C)NP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OC3=CC=CC=C3.C1CC2CC1N3C(O2)CN4C=C(C(=O)C(=C4C3=O)O)C(=O)NCC5=C(C=C(C=C5F)F)F.C1C(OC(S1)CO)N2C=C(C(=NC2=O)N)F
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| InChI |
1S/C21H18F3N3O5.C21H29N6O5P.C8H10FN3O3S/c22-9-3-14(23)12(15(24)4-9)6-25-20(30)13-7-26-8-16-27(10-1-2-11(5-10)32-16)21(31)17(26)19(29)18(13)28;1-14(2)31-21(28)16(4)26-33(29,32-17-8-6-5-7-9-17)13-30-15(3)10-27-12-25-18-19(22)23-11-24-20(18)27;9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5/h3-4,7,10-11,16,29H,1-2,5-6,8H2,(H,25,30);5-9,11-12,14-16H,10,13H2,1-4H3,(H,26,29)(H2,22,23,24);1,5-6,13H,2-3H2,(H2,10,11,14)/t10-,11+,16+;15-,16+,33+;5-,6+/m010/s1
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| InChIKey |
GMIGIKGMWTUBHA-UKQLQXPXSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human immunodeficiency virus Integrase (HIV IN) | Target Info | Inhibitor | [1] |
| Human immunodeficiency virus Reverse transcriptase (HIV RT) | Target Info | Inhibitor | [1] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. | |||
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