Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01GXL
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| Former ID |
DIB014674
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| Drug Name |
REP8839
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| Synonyms |
REP-8839; SB-682150; 2-[3-[4-Bromo-5-(1-fluorovinyl)-3-methylthien-2-ylmethylamino]propylamino]quinolin-4(1H)-one
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| Drug Type |
Small molecular drug
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| Indication | Bacterial infection [ICD-11: 1A00-1C4Z; ICD-10: A00-B99] | Phase 1 | [1] | |
| Company |
Replidyne
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| Structure |
 |
Download2D MOL |
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| Formula |
C20H21BrFN3OS
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| Canonical SMILES |
CC1=C(SC(=C1Br)C(=C)F)CNCCCNC2=CC(=O)C3=CC=CC=C3N2
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| InChI |
1S/C20H21BrFN3OS/c1-12-17(27-20(13(2)22)19(12)21)11-23-8-5-9-24-18-10-16(26)14-6-3-4-7-15(14)25-18/h3-4,6-7,10,23H,2,5,8-9,11H2,1H3,(H2,24,25,26)
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| InChIKey |
BGJMKHPWCFXMOW-UHFFFAOYSA-N
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| CAS Number |
CAS 757942-43-1
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Streptococcus Methionyl-tRNA synthetase (Stre-coc metG) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Selenocompound metabolism | |||
| Aminoacyl-tRNA biosynthesis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Antibacterial activity of REP8839, a new antibiotic for topical use. Antimicrob Agents Chemother. 2005 Oct;49(10):4247-52. | |||
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