Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01GUS
|
|||
| Former ID |
DAP000960
|
|||
| Drug Name |
Udenafil
|
|||
| Synonyms |
Zydena; DA 8159; DA-8159; Zydena (TN); 3-(1-methyl-7-oxo-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-[2-(1-methylpyrrolidin-2-yl)ethyl]-4-propoxybenzenesulfonamide; 5-(2-Propyloxy-5-(1-methyl-2-pyrollidinylethylamidosulfonyl)phenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo(4,3-d)pyrimidine-7-one
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Erectile dysfunction [ICD-11: HA01.1; ICD-10: N48.4; ICD-9: 302.72, 607.84] | Approved | [1] | |
| Therapeutic Class |
Vasodilator Agents
|
|||
| Company |
Dong-A Pharmaceutical
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C25H36N6O4S
|
|||
| Canonical SMILES |
CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)NCCC4CCCN4C)OCCC)C
|
|||
| InChI |
1S/C25H36N6O4S/c1-5-8-20-22-23(31(4)29-20)25(32)28-24(27-22)19-16-18(10-11-21(19)35-15-6-2)36(33,34)26-13-12-17-9-7-14-30(17)3/h10-11,16-17,26H,5-9,12-15H2,1-4H3,(H,27,28,32)
|
|||
| InChIKey |
IYFNEFQTYQPVOC-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 268203-93-6
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
12015432, 15181651, 16896098, 17194940, 43529893, 50430522, 57371963, 99443240, 99452560, 104178316, 114788102, 134224591, 134338234, 134340602, 135271929, 135626747, 137082780, 137237692, 138091955, 138937364, 141714788, 152041640, 160687015, 160967855, 163108842, 164235286, 164766037, 176251591, 196411563, 210275732, 210281393, 223922924, 226492530, 246737278
|
|||
| ChEBI ID |
CHEBI:135926
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Phosphodiesterase 5A (PDE5A) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Purine metabolism | |||
| cGMP-PKG signaling pathway | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Reactome | cGMP effects | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 2 | Increased expression of the nitric oxide synthase gene and protein in corpus cavernosum by repeated dosing of udenafil in a rat model of chemical d... Asian J Androl. 2009 Jul;11(4):435-42. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.