Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01EWH
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| Drug Name |
Quinolinyl compound 1
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| Synonyms |
PMID25828189-Compound-23
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| Drug Type |
Small molecular drug
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| Company |
PFIZER INC. DIDIUK, Mary FILIPSKI, Kevin J. GUZMAN-PEREZ, Angel LEE, Esther C. PFEFFERKORN, Jeffrey A. STEVENS, Benjamin TU, Meihua
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| Structure |
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glucagon receptor (GCGR) | Target Info | Antagonist | [1] |
| Target's Patent Info | Glucagon receptor (GCGR) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Glucagon signaling pathway | ||||
| Reactome | Glucagon signaling in metabolic regulation | |||
| G alpha (q) signalling events | ||||
| G alpha (s) signalling events | ||||
| Glucagon-type ligand receptors | ||||
| WikiPathways | GPCRs, Class B Secretin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Integration of energy metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. | |||
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