Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01EJJ
|
|||
| Former ID |
DIB005412
|
|||
| Drug Name |
JTE-051
|
|||
| Indication | Plaque psoriasis [ICD-11: EA90.0; ICD-10: L40.0] | Phase 2 | [1] | |
| Allergy [ICD-11: 4A80-4A85; ICD-10: T78.4; ICD-9: 995.3] | Phase 1 | [2] | ||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | T-cell-specific kinase (ITK) | Target Info | Inhibitor | [3] |
| KEGG Pathway | Chemokine signaling pathway | |||
| T cell receptor signaling pathway | ||||
| Leukocyte transendothelial migration | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Fc-epsilon receptor I signaling in mast cells | |||
| TCR signaling in naï | ||||
| Class I PI3K signaling events | ||||
| Reactome | Generation of second messenger molecules | |||
| FCERI mediated Ca+2 mobilization | ||||
| WikiPathways | TCR Signaling Pathway | |||
| T-Cell Receptor and Co-stimulatory Signaling | ||||
| TCR signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800035711) | |||
| REF 3 | Characterisation of a K390R ITK Kinase Dead Transgenic Mouse - Implications for ITK as a Therapeutic Target. PLoS One. 2014; 9(9): e107490. | |||
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