Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01EFO
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| Former ID |
DIB010452
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| Drug Name |
CGP-53716
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| Synonyms |
CGS-53716
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Terminated | [1] | |
| Company |
Novartis AG
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| Structure |
 |
Download2D MOL |
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| Formula |
C23H19N5O
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| Canonical SMILES |
CC1=C(C=C(C=C1)NC(=O)C2=CC=CC=C2)NC3=NC=CC(=N3)C4=CN=CC=C4
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| InChI |
1S/C23H19N5O/c1-16-9-10-19(26-22(29)17-6-3-2-4-7-17)14-21(16)28-23-25-13-11-20(27-23)18-8-5-12-24-15-18/h2-15H,1H3,(H,26,29)(H,25,27,28)
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| InChIKey |
UOEJSOXEHKCNAE-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Platelet-derived growth factor receptor (PDGFR) | Target Info | Modulator | [2], [3], [4] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005535) | |||
| REF 2 | Inhibition of cell growth: effects of the tyrosine kinase inhibitor CGP 53716. J Pharmacol Exp Ther. 1997 Oct;283(1):402-10. | |||
| REF 3 | Inhibition of platelet-derived growth factor receptor tyrosine kinase inhibits vascular smooth muscle cell migration and proliferation. FASEB J. 1997 Nov;11(13):1119-26. | |||
| REF 4 | Role of platelet-derived growth factor in obliterative bronchiolitis (chronic rejection) in the rat. Am J Respir Crit Care Med. 1999 Oct;160(4):1324-32. | |||
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