Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01EDO
|
|||
| Former ID |
DIB001383
|
|||
| Drug Name |
GW-250495
|
|||
| Synonyms |
GR-250495; GR-250495X; GW-250495X
Click to Show/Hide
|
|||
| Indication | Asthma [ICD-11: CA23; ICD-10: J45, J45.8; ICD-9: 493] | Discontinued in Phase 1 | [1] | |
| Company |
Glaxo Wellcome plc
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Estrogen-related receptor-alpha (ESRRA) | Target Info | Agonist | [2] |
| Reactome | PPARA activates gene expression | |||
| Transcriptional activation of mitochondrial biogenesis | ||||
| Nuclear Receptor transcription pathway | ||||
| WikiPathways | Mitochondrial Gene Expression | |||
| Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010129) | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 622). | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.