Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01BXE
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| Former ID |
DIB019147
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| Drug Name |
CITCO
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| Synonyms |
CITCO; 338404-52-7; UNII-D77H8321PB; 6-(4-CHLOROPHENYL)IMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBALDEHYDE O-(3,4-DICHLOROBENZYL)OXIME; CHEMBL458603; D77H8321PB; 6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime; 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime; CITCO cpd; Spectrum5_001974; BSPBio_001028; SCHEMBL241281; DTXSID4040761; CHEBI:92928; BCBcMAP01_000217; 6-[4-Chlorophenyl]imidazo[2,1-b][1,3]thiazole-5-carbaldehydeo-[3,4-dichlorobenzyl]oxime
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C19H12Cl3N3OS
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| Canonical SMILES |
C1=CC(=CC=C1C2=C(N3C=CSC3=N2)C=NOCC4=CC(=C(C=C4)Cl)Cl)Cl
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| InChI |
1S/C19H12Cl3N3OS/c20-14-4-2-13(3-5-14)18-17(25-7-8-27-19(25)24-18)10-23-26-11-12-1-6-15(21)16(22)9-12/h1-10H,11H2/b23-10+
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| InChIKey |
ZQWBOKJVVYNKTL-AUEPDCJTSA-N
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| CAS Number |
CAS 338404-52-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
854372, 7886607, 17396629, 24016238, 24724448, 25795375, 26756451, 26756452, 26756453, 26758472, 29216414, 44736028, 47498114, 48093098, 48317021, 48392500, 50111366, 50267643, 53790778, 57373266, 85287714, 85787274, 89714607, 92310050, 99300962, 99302482, 103647957, 109634513, 135337076, 135697963, 162248406, 163688364, 187071860, 198935661, 223369972, 226591793, 241071559, 252157451, 252343227, 252455774
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| ChEBI ID |
CHEBI:92928
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Orphan nuclear receptor NR1I3 (NR1I3) | Target Info | Agonist | [2] |
| Pathway Interaction Database | Glucocorticoid receptor regulatory network | |||
| WikiPathways | Nuclear Receptors in Lipid Metabolism and Toxicity | |||
| Nuclear Receptors Meta-Pathway | ||||
| Constitutive Androstane Receptor Pathway | ||||
| Drug Induction of Bile Acid Pathway | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2758). | |||
| REF 2 | Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. J Biol Chem. 2003 May 9;278(19):17277-83. | |||
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