Drug Information
Drug General Information | Top | |||
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Drug ID |
D01BCK
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Former ID |
DNC013435
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Drug Name |
N-hydroxy-1-naphthamide
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Synonyms |
1-Naphthohydroxamic acid; 6953-61-3; N-Hydroxy-1-naphthamide; 1-NAPHTHALENECARBOXAMIDE, N-HYDROXY-; NSC 57457; N-Hydroxynaphthalene-1-carboxamide; alpha-Naphthohydroxamic acid; a-Naphthohydroxamic acid; BRN 2094470; CHEMBL115468; Naphthalene-1-carboxylic acid hydroxyamide; 8GK; naphthylhydroxamic acid; AC1L2M8D; N-Hydroxy-1-naphthamide #; 4-09-00-02407 (Beilstein Handbook Reference); .alpha.-Naphthohydroxamic acid; ACMC-209o98; SCHEMBL2230679; CTK5D0341; DTXSID30219789; JRZGPWOEHDOVMC-UHFFFAOYSA-N
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C11H9NO2
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Canonical SMILES |
C1=CC=C2C(=C1)C=CC=C2C(=O)NO
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InChI |
1S/C11H9NO2/c13-11(12-14)10-7-3-5-8-4-1-2-6-9(8)10/h1-7,14H,(H,12,13)
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InChIKey |
JRZGPWOEHDOVMC-UHFFFAOYSA-N
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CAS Number |
CAS 6953-61-3
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Histone deacetylase 8 (HDAC8) | Target Info | Inhibitor | [1] |
KEGG Pathway | Alcoholism | |||
Viral carcinogenesis | ||||
Panther Pathway | Wnt signaling pathway | |||
Pathway Interaction Database | Signaling events mediated by HDAC Class I | |||
Reactome | NOTCH1 Intracellular Domain Regulates Transcription | |||
Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
HDACs deacetylate histones | ||||
WikiPathways | Integrated Pancreatic Cancer Pathway | |||
Neural Crest Differentiation | ||||
Cell Cycle |
References | Top | |||
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REF 1 | Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8. |
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