Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00YUB
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| Former ID |
DIB003205
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| Drug Name |
NT-3
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| Synonyms |
Neurotrophin-3; NT-3, Amgen-Regeneron Partners; NT-3, Amgen/ Regeneron; Neurotrophin-3, Amgen-Regeneron Partners; Neurotrophin-3, Amgen/ Regeneron
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| Indication | Constipation [ICD-11: DD91.1; ICD-10: K59.0; ICD-9: 564] | Discontinued in Phase 2 | [1], [2] | |
| Company |
Takeda Pharmaceutical Co Ltd
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Neurotrophin-3 (NTF3) | Target Info | Modulator | [3] |
| KEGG Pathway | MAPK signaling pathway | |||
| Neurotrophin signaling pathway | ||||
| Pathway Interaction Database | SHP2 signaling | |||
| p75(NTR)-mediated signaling | ||||
| Neurotrophic factor-mediated Trk receptor signaling | ||||
| Trk receptor signaling mediated by the MAPK pathway | ||||
| WikiPathways | BDNF signaling pathway | |||
| Integrated Pancreatic Cancer Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5033). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005227) | |||
| REF 3 | NT-3. Takeda/Regeneron/Amgen. IDrugs. 2001 Jul;4(7):820-4. | |||
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