Drug Information
Drug General Information | Top | |||
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Drug ID |
D00WUF
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Former ID |
DIB013631
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Drug Name |
Pregabalin
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Synonyms |
Pregabalin CR; Pregabalin (controlled-release, oral); Pregabalin (controlled-release, oral), Pfizer
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Drug Type |
Small molecular drug
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Indication | Chronic obstructive pulmonary disease [ICD-11: CA22; ICD-10: J44, J44.9] | Approved | [1], [2] | |
Company |
Pfizer
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Structure |
Download2D MOL |
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Formula |
C8H17NO2
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Canonical SMILES |
CC(C)CC(CC(=O)O)CN
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InChI |
1S/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)/t7-/m0/s1
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InChIKey |
AYXYPKUFHZROOJ-ZETCQYMHSA-N
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CAS Number |
CAS 148553-50-8
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PubChem Compound ID | ||||
PubChem Substance ID |
11694138, 12011767, 12014780, 15171006, 15219358, 17396883, 39472930, 46504934, 49831059, 49976228, 56365856, 57364178, 78321978, 92719096, 99431952, 103290097, 104050134, 104253343, 109692704, 113994486, 118046909, 118310941, 124772316, 126621090, 126659034, 126670344, 127479071, 131299586, 131403159, 134338500, 135081614, 135668336, 135684252, 136995650, 137006522, 142340821, 144205028, 160963578, 162111182, 163180654, 163621090, 163686413, 163801871, 164198004, 174006288, 175267702, 175612209, 178102131, 179149961, 184557778
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ChEBI ID |
CHEBI:64356
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ADReCS Drug ID | BADD_D01835 |
Target and Pathway | Top | |||
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Target(s) | Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) | Target Info | Modulator | [2] |
KEGG Pathway | MAPK signaling pathway | |||
Cardiac muscle contraction | ||||
Adrenergic signaling in cardiomyocytes | ||||
Oxytocin signaling pathway | ||||
Hypertrophic cardiomyopathy (HCM) | ||||
Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ||||
Dilated cardiomyopathy | ||||
Panther Pathway | Muscarinic acetylcholine receptor 2 and 4 signaling pathway | |||
WikiPathways | Arrhythmogenic Right Ventricular Cardiomyopathy | |||
miR-targeted genes in muscle cell - TarBase | ||||
miR-targeted genes in lymphocytes - TarBase |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5484). | |||
REF 2 | Pregabalin reduces the release of synaptic vesicles from cultured hippocampal neurons. Mol Pharmacol. 2006 Aug;70(2):467-76. |
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