Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00VPU
|
|||
| Former ID |
DCL000993
|
|||
| Drug Name |
SLV-323
|
|||
| Indication | Chemotherapy-induced nausea [ICD-11: MD90; ICD-10: R11] | Discontinued in Phase 1 | [1] | |
| Gastric motility disorder [ICD-11: DA21; ICD-10: K22.4] | Discontinued in Phase 1 | [1] | ||
| Irritable bowel syndrome [ICD-11: DD91.0; ICD-10: K55-K64, K58] | Discontinued in Phase 1 | [1] | ||
| Company |
Solvay
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Substance-P receptor (TACR1) | Target Info | Modulator | [1] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Measles | ||||
| Panther Pathway | CCKR signaling map ST | |||
| Reactome | G alpha (q) signalling events | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Spinal Cord Injury | ||||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Emerging drugs for chemotherapy-induced emesis. Expert Opin Emerg Drugs. 2006 Mar;11(1):137-51. | |||
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