Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00UVA
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| Former ID |
DNAP001267
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| Drug Name |
Carfilzomib
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| Synonyms |
Carfilzomib; 868540-17-4; Kyprolis; Carfilzomib (PR-171); PR-171; UNII-72X6E3J5AR; 72X6E3J5AR; CHEMBL451887; CHEBI:65347; NCGC00249613-01; DSSTox_RID_82886; DSSTox_CID_28616; DSSTox_GSID_48690; (S)-4-methyl-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide; N-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-{(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl}-L-phenylalaninamide
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| Drug Type |
Small molecular drug
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| Indication | Multiple myeloma [ICD-11: 2A83; ICD-10: C90.0] | Approved | [1], [2] | |
| Small-cell lung cancer [ICD-11: 2C25.Y; ICD-9: 162.9] | Phase 1/2 | [3] | ||
| Company |
Onyx Pharmaceuticals
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| Structure |
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Download2D MOL |
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| Formula |
C40H57N5O7
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| Canonical SMILES |
CC(C)CC(C(=O)C1(CO1)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CCC3=CC=CC=C3)NC(=O)CN4CCOCC4
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| InChI |
1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/t31-,32-,33-,34-,40+/m0/s1
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| InChIKey |
BLMPQMFVWMYDKT-NZTKNTHTSA-N
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| CAS Number |
CAS 868540-17-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
16658822, 16812122, 23677375, 42698607, 79448448, 92309411, 96025563, 103652542, 104120353, 124360326, 124955654, 126666807, 135195928, 137232018, 139716850, 144206630, 152159713, 160644888, 162012022, 162220763, 163423918, 163620703, 163686020, 164041848, 170466878, 172918803, 174006371, 174531085, 175266683, 175427135, 178103992, 186014508, 189158922, 198993058, 223377621, 223683622, 223704692, 224740444, 226463473, 242082461, 248344031, 249814475, 251970960, 252451821, 252553657
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| ChEBI ID |
CHEBI:65347
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| ADReCS Drug ID | BADD_D00367 | |||
| SuperDrug ATC ID |
L01XX45
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Proteasome (PS) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7420). | |||
| REF 2 | Nat Rev Drug Discov. 2013 Feb;12(2):87-90. | |||
| REF 3 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
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