Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00UUM
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| Former ID |
DNC001135
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| Drug Name |
PMEA
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| Synonyms |
ADEFOVIR; 106941-25-7; PMEA; ((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid; 9-(2-Phosphonylmethoxyethyl)adenine; GS-0393; GS 0393; GS 393; 9-(2-(Phosphonomethoxy)ethyl)adenine; N-(2-Phosphonylmethoxyethyl)adenine; DRG-0156; UNII-6GQP90I798; C8H12N5O4P; HSDB 8079; CHEMBL484; 2-(6-aminopurin-9-yl)ethoxymethylphosphonic acid; BRN 3561094; {[2-(6-Amino-9h-Purin-9-Yl)ethoxy]methyl}phosphonic Acid; N-(2-Phophonomethoxyethyl-2,6-diaminopurine); Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]-; 6GQP90I798
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C8H12N5O4P
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| Canonical SMILES |
C1=NC(=C2C(=N1)N(C=N2)CCOCP(=O)(O)O)N
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| InChI |
1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16)
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| InChIKey |
SUPKOOSCJHTBAH-UHFFFAOYSA-N
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| CAS Number |
CAS 106941-25-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
13454, 595933, 7603301, 7978643, 8186704, 14824193, 17396926, 29216223, 43117603, 49830270, 50007435, 51018760, 53787044, 57313993, 87244997, 92712358, 103169255, 103915595, 104320054, 117626702, 118048666, 118845559, 125337359, 126625632, 126656759, 126671263, 127310178, 127310179, 127310180, 129291120, 131541873, 135016825, 135684379, 136375753, 137038437, 142415946, 143493306, 144080335, 144205435, 152242349, 162036477, 162177481, 163673274, 164786964, 172912778, 173132047, 174477194, 174548941, 175267397, 175423217
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| ChEBI ID |
CHEBI:2469
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| ADReCS Drug ID | BADD_D00043 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Herpes simplex virus DNA polymerase UL30 (HSV UL30) | Target Info | Inhibitor | [1] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Herpes simplex virus-specified DNA polymerase is the target for the antiviral action of 9-(2-phosphonylmethoxyethyl)adenine. J Biol Chem. 1991 Jan 5;266(1):238-44. | |||
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