Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00QVT
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| Former ID |
DIB012298
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| Drug Name |
ATN-161
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| Synonyms |
PHSCN; PHSCN, University of Michigan; Angiogenesis inhibitors (cancer), Attenuon; Integrin antagonists (cancer), Attenuon; Ac-PHSCN-NH2, University of Michigan
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| Drug Type |
Small molecular drug
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| Indication | Renal cell carcinoma [ICD-11: 2C90; ICD-10: C64] | Phase 2 | [1] | |
| Company |
University of Michigan
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| Structure |
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Download2D MOL |
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| Formula |
C23H35N9O8S
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| Canonical SMILES |
CC(=O)N1CCCC1C(=O)NC(CC2=CN=CN2)C(=O)NC(CO)C(=O)NC(CS)C(=O)NC(CC(=O)N)C(=O)N
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| InChI |
1S/C23H35N9O8S/c1-11(34)32-4-2-3-17(32)23(40)29-14(5-12-7-26-10-27-12)20(37)30-15(8-33)21(38)31-16(9-41)22(39)28-13(19(25)36)6-18(24)35/h7,10,13-17,33,41H,2-6,8-9H2,1H3,(H2,24,35)(H2,25,36)(H,26,27)(H,28,39)(H,29,40)(H,30,37)(H,31,38)/t13-,14-,15-,16-,17-/m0/s1
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| InChIKey |
MMHDBUJXLOFTLC-WOYTXXSLSA-N
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| CAS Number |
CAS 262438-43-7
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| PubChem Compound ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00131651) ATN-161 in Advanced Renal Cell Cancer. U.S. National Institutes of Health. | |||
| REF 2 | A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo. Mol Cancer Ther. 2006 Sep;5(9):2271-80. | |||
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