Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00QJA
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| Drug Name |
Biphenyl carboxamidopropanoic acid derivative 4
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| Synonyms |
PMID25828189-Compound-9
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| Drug Type |
Small molecular drug
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| Company |
JANSSEN PHARMACEUTICA NV CHAKRAVARTY, Devraj GRECO, Michael, N. SHOOK, Brian XU, Guozhang ZHANG, Rui
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| Structure |
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Download2D MOL |
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| Formula |
C33H27ClF6N2O3
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| Canonical SMILES |
CC1=C(C=CC(=C1)C(=O)NCCC(=O)O)C2=C(C=CC(=C2)C(F)(F)F)CNC3=CC(=C(C=C3)C4=C(C=C(C=C4)C(F)(F)F)C)Cl
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| InChI |
1S/C33H27ClF6N2O3/c1-18-13-20(31(45)41-12-11-30(43)44)4-8-26(18)28-15-23(33(38,39)40)5-3-21(28)17-42-24-7-10-27(29(34)16-24)25-9-6-22(14-19(25)2)32(35,36)37/h3-10,13-16,42H,11-12,17H2,1-2H3,(H,41,45)(H,43,44)
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| InChIKey |
DUDZHUBPDPKULT-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glucagon receptor (GCGR) | Target Info | Antagonist | [1] |
| Target's Patent Info | Glucagon receptor (GCGR) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Glucagon signaling pathway | ||||
| Reactome | Glucagon signaling in metabolic regulation | |||
| G alpha (q) signalling events | ||||
| G alpha (s) signalling events | ||||
| Glucagon-type ligand receptors | ||||
| WikiPathways | GPCRs, Class B Secretin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Integration of energy metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. | |||
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