Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00QIK
|
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| Former ID |
DNC001158
|
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| Drug Name |
PS-519
|
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| Indication | Ischemia-reperfusion injury [ICD-11: DB98.B; ICD-10: I00-I99] | Terminated | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C12H19NO4
|
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| Canonical SMILES |
CCCC1C2C(C(=O)O2)(NC1=O)C(C(C)C)O
|
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| InChI |
1S/C12H19NO4/c1-4-5-7-9-12(11(16)17-9,13-10(7)15)8(14)6(2)3/h6-9,14H,4-5H2,1-3H3,(H,13,15)/t7-,8+,9+,12-/m1/s1
|
|||
| InChIKey |
KMXHEXRPYSXLRN-JDVQERKKSA-N
|
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:52724
|
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Proteasome (PS) | Target Info | Modulator | [2], [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009964) | |||
| REF 2 | Effect of the proteasome inhibitor MLN519 on the expression of inflammatory molecules following middle cerebral artery occlusion and reperfusion in... Neurotox Res. 2003;5(7):505-14. | |||
| REF 3 | Delayed treatment with MLN519 reduces infarction and associated neurologic deficit caused by focal ischemic brain injury in rats via antiinflammato... J Cereb Blood Flow Metab. 2003 Jan;23(1):75-87. | |||
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